With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42972-13-4,1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid,as a common compound, the synthetic route is as follows.
Bromo-4-oxo-3,4-dihydro–phthalazine-6-carboxylic acid: 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid (91.0 g, 0.44 mol) was suspended in DCE (1.0 L) and phosphorus pentabromide (761.0 g, 1.77 mol) was added in three portions and the reaction heated to reflux for 24 hours. The reaction was cooled to RT and poured onto ice (2.50 kg) and the resulting precipitate filtered and washed with water to give the crude product (130 g).
42972-13-4 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid 309056, aphthalazine compound, is more and more widely used in various.
Reference£º
Patent; Roche Palo Alto LLC; US2007/219195; (2007); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem