With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.
General procedure: Anhydrous potassium carbonate (0.009 mol) was added to appropriate 1(2H)-phthalazinone derivative (0.003 mol) in 7 mL of anhydrous DMF. Subsequently, 1-bromo-2-chloroethane (0.009 mol) was added to this solution and reaction mixture was stirred at room temperature for 2.5 h. Then, the reaction mixture was poured into ice water and the precipitate was filtered to yield compound (4, 5 and 6), which was used for the next step without further purification. 2-(2-Chloroethyl)phthalazin-1(2H)-one (4). White solid, mp 98-101C, ESI-HRMS m/z: Calcd. for C10H10ClN2O (MH+), 209.0482, found 209.0472., 119-39-1
The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kilic, Burcu; Guelcan, Hayrettin Ozan; Yalcin, Mertcan; Aksakal, Fatma; Dimoglo, Anatoli; ?ahin, Mustafa Fethi; Do?ruer, Deniz Songuel; Letters in drug design and discovery; vol. 14; 2; (2017); p. 159 – 166;,
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