Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of sodium methoxide (0.0165 mol) in dry MeOH (70 ml) was added 2H-phthalazin-1-one 1 (0.0153 mol). The mixture was heated to boiling for 30 minutes. Afterwards, toluene-4-sulfonic acid 2-[methyl-(toluene-4-sulfonyl)-amino]-ethyl ester (6) (0.0230 mol) was added and heating was continued for next 7 hrs. After this time, the mixture was cooled to ambient temperature. The separated product was filtrated off, washed with dry methanol and purified by crystallization or column chromatography.

119-39-1, The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: In a Schlenk tube charged with a stirring bar, the air-stable bidentate Lewis acid catalyst B (5.00 mol percent) and the stated solvent were added under N2. Then, the phthalazine (1.00 equiv), dienophile (2.00 equiv; for enamines, generated in situ from aldehyde and amine) were added subsequently. The reaction mixture was stirred at the given temperature. After the reaction was finished, the solvent was removed. The remaining residue was purified by flash column chromatography over SiO2 to obtain the product., 253-52-1

As the paragraph descriping shows that 253-52-1 is playing an increasingly important role.

Reference£º
Article; Hong, Longcheng; Ahles, Sebastian; Heindl, Andreas H.; Tietcha, Gastelle; Petrov, Andrey; Lu, Zhenpin; Logemann, Christian; Wegner, Hermann A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 618 – 625;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

A solution of 2H-phthalazin-1-one (1.33 g, 9.1 mmol) in tetrahydrofuran (45.5 mL, 0.2M) cooled to 0 C. was treated with a 60% dispersion of sodium hydride in mineral oil (437 mg, 10.9 mmol). The reaction was stirred at 0 C. for 5 min and then at 25 C. for 30 min. After this time, the reaction was treated with 2-bromo-3-cyclopentyl-propionic acid methyl ester (Intermediate 10, 2.35 g, 10 mmol). The reaction was then warmed to 50 C. where it stirred overnight. At this time, the reaction was cooled to 25 C., poured into water (100 mL), and extracted with methylene chloride (3¡Á100 mL). The organics were dried over sodium sulfate, filtered and concentrated in vacuo. Silica gel column chromatography (ISCO, 80 g, 20-50% ethyl acetate/hexanes) afforded 3-cyclopentyl-2-(1-oxo-1H-phthalazin-2-yl)-propionic acid methyl ester (1.78 g, 61%) as a clear oil; ES+-HRMS m/e calcd for C17H20N2O3 [M+H+] 301.1547 found 301.1546., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; Berthel, Steven Joseph; Haynes, Nancy-Ellen; Kester, Robert Francis; McDermott, Lee Apostle; Qian, Yimin; Sarabu, Ramakanth; Scott, Nathan Robert; Tilley, Jefferson Wright; US2009/264434; (2009); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Phthalazin-1(2H)-one, cas is 119-39-1, it is a common heterocyclic compound, the phthalazine compound, its synthesis route is as follows.,119-39-1

Method A The Mitsunobu reaction was carried out under argon. Diethyl azodicarboxylate (1.03 mmol, solution in toluene c?40%) was slowly added to a stirred solution of triphenylphosphine (1.03 mmol) in dry THF (10mL) at the temperature between -10C and -5C. Then a solution of phthalazinone 2 (0.684 mmol) in THF (10 mL) was added dropwise. The whole lot was mixed for 15 min at this temperature and next the appropriate alcohol (0.753 mmol) in THF (5 mL) was added at -10 to -5C. The mixture was stirred during 2 h at this conditions, after, which time the reaction mixture was warmed to ambient temperature and stirred in this conditions for 24h. All volatile materials were removed under reduced pressure, ethyl ether (5 mL) was added to the residue, and the whole lot was stirred for 0.5 h at an ambient temperature. The separate white solid was collected by flirtation and washed with ether, and the filtrate was evaporated to dryness. The product was separated and purified by flash chromatography. Method B The Mitsunobu reaction was carried out under argon. To a round bottom flask were added phthalazinone 2 or 3 (1.78 mmol), alcohol (2.67 mmol), triphenylphosphine (2.67 mmol) and THF (40 mL). Then, the solution was cooled to the temperature -20C for 15 min and diethyl azodicarboxylate (2.67mmol, solution in toluene c?40%) was added dropwise to the solution. The reaction was stirred at -20C for 1h, and then the cold bath allowed to slowly warm to an ambient temperature and stirred in this conditions for 24h. All volatile materials were removed under reduced pressure, diethyl ether (15 mL) was added to the residue, and the whole lot was stirred for 0.5 h at an ambient temperature. The separate white solid was collected by flirtation and washed with ether, and the filtrate was evaporated to dryness. The product was separated and purified by flash chromatography. 2-(Butan-2-yl)phthalazin-1(2H)-one (10a) Straw oil; Yield: 41.5 mg, 30% (Method A), 259 mg, 72% (Method B); Rf (AcOEt/Hex 1:3)=0.5; FTIR (thin film): nu=3044, 2968, 2933, 1644 (C=O), 1591 cm-1; 1H NMR (600 MHz, CDCl3): delta=8.43 (d, J=7.8 Hz, 1H, 8 Ar-H), 8.20 (s, 1H, 4-pyrid), 7.80-7.71 (m, 2H, Ar-H), 7.67 (d, J=8.2 Hz, 1H, 5 Ar-H), 5.38-5.06 (m, 1H, N-CH), 1.95-1.86 (m, 1H, CH2), 1.77-1.68 (m, 1H, CH2), 1.37 (d, J=6.8 Hz, 3H, Me), 0.84 (t, J=7.4 Hz, 3H, Me); 13C NMR (150 MHz, CDCl3): delta=159.6 (C=O), 137.7, 133.0, 131.5, 129.4, 128.0, 127.1, 125.9, 54.1 (N-CH), 28.4, 19.4, 10.9 ppm; HRMS (ESI) m/z: calcd for C12H15N2O [M+H]+ 203.1179, found 203.1179.

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Fornal, Emilia; Sieroci?ska, Beata; Czeczko, Renata; Nowak, Monika; Tetrahedron; vol. 72; 49; (2016); p. 7942 – 7951;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Phthalazin-1(2H)-one, cas is 119-39-1, it is a common heterocyclic compound, the phthalazine compound, its synthesis route is as follows.,119-39-1

General procedure: The Mitsunobu reaction was carried out under argon. To a stirred solution of TPP (0,0102 mol) in dry THF (10 ml) was slowly added DEAD (0,0102 mol, solution in toluene c ? 40%) at -10C. Then a solution of phthalazinone 1 (0.0068 mol) in THF (44 ml) was added dropwise. The whole lot was mixed for 15 min at -10C and next was added the appropriate derivative of N-methylethanolamine 7 or 8 (0.00748 mol) in THF (5 ml) at -10C. The mixture was stirred during 2 hrs at -10C, after which time, the reaction mixture was warmed to ambient temperature and stirred in this conditions for 20 hrs. All volatile materials were removed under reduced pressure, ethyl ether (20ml) was added to the residue and the whole lot was stirred for 0.5 hrs at ambient temperature. The separate white solid was collected by flirtation, washed with ether and filtrate was evaporated to dryness. The residue was subjected to column chromatography to give the pure product 11.

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The precursor lactam (1 mmol) was dissolved in DMF-TEA 1:1(2 mL), then K2CO3 (0.410 g, 3 mmol), CuI (190 mg, 1 mmol),PdCl2(PPh3)2 (17.5 mg, 0.025 mmol) and aryl halide (1.1 mmol)were added to the solution. The reaction mixture was stirred underargon, at 110C for overnight. The reaction mixture was ltered andbrine (30 mL) was added to the solution. The precipitated solid wasltered off then washed with brine and water. The crude productwas puried by column chromatography (on silica, using DCM orDCM-MeOH 100-5:1 mixtures as eluent) and subsequent crystal-lization from MeOH, EtOH,iPrOH,tBuOH, MeOH-water or EtOH-water., 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Jernei, Tamas; B?sze, Szilvia; Szabo, Rita; Hudecz, Ferenc; Majrik, Katalin; Csampai, Antal; Tetrahedron; vol. 73; 43; (2017); p. 6181 – 6192;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: (NH4)2C2O4¡¤H2O (0.085g, 0.60mmol) was dissolved in water (5ml) and slowly added to the methanolic solution of CuCl2¡¤2H2O (0.1g; 0.59mmol) and suitable N-donor ligand. The resulting solution was kept for evaporation at room temperature, and after a few days green crystals of 1, 2 and 3 were obtained, filtered off and dried in air., 253-52-1

253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Machura; Switlicka-Olszewska; Kruszynski; Gron; Oboz; Duda; Polyhedron; vol. 62; (2013); p. 158 – 168;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of sodium azide (0.085 g, 1.3 mmol) in water (10 ml) was slowly added to the methanolic solution (15 ml) of Cd(NO3)24H2O (0.2 g, 0.65 mmol) and quinazoline (0.17 g, 1.30 mmol) and stirred at room temperature for 12 h. Light yellow crystalline precipitate of [Cd(Qnz)2(N3)2]n was collected in 70percent yield. The crystals suitable for X-ray structure determination were obtained by slow recrystallization from methanol

253-52-1, As the paragraph descriping shows that 253-52-1 is playing an increasingly important role.

Reference£º
Article; Machura; Nawrot; Kruszynski; Dulski; Polyhedron; vol. 54; (2013); p. 272 – 284;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Method A The Mitsunobu reaction was carried out under argon. Diethyl azodicarboxylate (1.03 mmol, solution in toluene c?40%) was slowly added to a stirred solution of triphenylphosphine (1.03 mmol) in dry THF (10mL) at the temperature between -10C and -5C. Then a solution of phthalazinone 2 (0.684 mmol) in THF (10 mL) was added dropwise. The whole lot was mixed for 15 min at this temperature and next the appropriate alcohol (0.753 mmol) in THF (5 mL) was added at -10 to -5C. The mixture was stirred during 2 h at this conditions, after, which time the reaction mixture was warmed to ambient temperature and stirred in this conditions for 24h. All volatile materials were removed under reduced pressure, ethyl ether (5 mL) was added to the residue, and the whole lot was stirred for 0.5 h at an ambient temperature. The separate white solid was collected by flirtation and washed with ether, and the filtrate was evaporated to dryness. The product was separated and purified by flash chromatography. Method B The Mitsunobu reaction was carried out under argon. To a round bottom flask were added phthalazinone 2 or 3 (1.78 mmol), alcohol (2.67 mmol), triphenylphosphine (2.67 mmol) and THF (40 mL). Then, the solution was cooled to the temperature -20C for 15 min and diethyl azodicarboxylate (2.67mmol, solution in toluene c?40%) was added dropwise to the solution. The reaction was stirred at -20C for 1h, and then the cold bath allowed to slowly warm to an ambient temperature and stirred in this conditions for 24h. All volatile materials were removed under reduced pressure, diethyl ether (15 mL) was added to the residue, and the whole lot was stirred for 0.5 h at an ambient temperature. The separate white solid was collected by flirtation and washed with ether, and the filtrate was evaporated to dryness. The product was separated and purified by flash chromatography. 2-(Butan-2-yl)phthalazin-1(2H)-one (10a) Straw oil; Yield: 41.5 mg, 30% (Method A), 259 mg, 72% (Method B); Rf (AcOEt/Hex 1:3)=0.5; FTIR (thin film): nu=3044, 2968, 2933, 1644 (C=O), 1591 cm-1; 1H NMR (600 MHz, CDCl3): delta=8.43 (d, J=7.8 Hz, 1H, 8 Ar-H), 8.20 (s, 1H, 4-pyrid), 7.80-7.71 (m, 2H, Ar-H), 7.67 (d, J=8.2 Hz, 1H, 5 Ar-H), 5.38-5.06 (m, 1H, N-CH), 1.95-1.86 (m, 1H, CH2), 1.77-1.68 (m, 1H, CH2), 1.37 (d, J=6.8 Hz, 3H, Me), 0.84 (t, J=7.4 Hz, 3H, Me); 13C NMR (150 MHz, CDCl3): delta=159.6 (C=O), 137.7, 133.0, 131.5, 129.4, 128.0, 127.1, 125.9, 54.1 (N-CH), 28.4, 19.4, 10.9 ppm; HRMS (ESI) m/z: calcd for C12H15N2O [M+H]+ 203.1179, found 203.1179.

119-39-1, As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Article; Malinowski, Zbigniew; Fornal, Emilia; Sieroci?ska, Beata; Czeczko, Renata; Nowak, Monika; Tetrahedron; vol. 72; 49; (2016); p. 7942 – 7951;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

STAGE A 1,2-Dihydro-1-oxo-2-(tetrahydropyran-2-ylethoxy)-phthalazine A solution of 41.5 g of potassium hydroxide in 53 ml of water is added to a solution of 61 g of 1,2-dihydro-1-oxophthalazine in 430 ml of dimethyl sulfoxide. After one hour, 130 g of 2-(2-bromoethoxy)tetrahydropyran are added rapidly and the mixture is left stirring at 20 C. for 48 hours. The solution obtained is then diluted with 1200 ml of water, the product is extracted with dichloromethane and the organic phase is dried over anhydrous sodium sulfate and concentrated. Yield: 80% Proton nuclear magnetic resonance spectrum (200 MHz, solvent CDCl3): 1.3-2 ppm, m, 6H; 3.3-4.8 ppm, m+m, 1H+6H; 7.6-7.9 ppm, m, 3H; 8.15 ppm, s, 1H; 8.4 ppm, m, 1H., 119-39-1

The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Adir et Compagnie; US5028607; (1991); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem