Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: In a Schlenk tube charged with a stirring bar, the air-stable bidentate Lewis acid catalyst B (5.00 mol percent) and the stated solvent were added under N2. Then, the phthalazine (1.00 equiv), dienophile (2.00 equiv; for enamines, generated in situ from aldehyde and amine) were added subsequently. The reaction mixture was stirred at the given temperature.After the reaction was finished, the solvent was removed. The remaining residue was purified by flash column chromatography over SiO2 to obtain the product., 253-52-1

253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Hong, Longcheng; Ahles, Sebastian; Heindl, Andreas H.; Tietcha, Gastelle; Petrov, Andrey; Lu, Zhenpin; Logemann, Christian; Wegner, Hermann A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 618 – 625;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

General procedure: In a Schlenk tube charged with a stirring bar, the air-stable bidentate Lewis acid catalyst B (5.00 mol percent) and the stated solvent were added under N2. Then, the phthalazine (1.00 equiv), dienophile (2.00 equiv; for enamines, generated in situ from aldehyde and amine) were added subsequently. The reaction mixture was stirred at the given temperature.After the reaction was finished, the solvent was removed. The remaining residue was purified by flash column chromatography over SiO2 to obtain the product.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazine

Reference£º
Article; Hong, Longcheng; Ahles, Sebastian; Heindl, Andreas H.; Tietcha, Gastelle; Petrov, Andrey; Lu, Zhenpin; Logemann, Christian; Wegner, Hermann A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 618 – 625;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazin-1(2H)-one, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 119-39-1, its synthesis route is as follows.,119-39-1

1-(2H)-pyridazinone 1.00 g (6.84 mmol) and triphenylphosphine 1.79 g (6.84 mmol) were added to 25 ml of tetrahydrofuran, and 0.85 g (6.84 mmol) of 2-bromoethanol was added dropwise in an ice bath.After the dropwise addition was completed, 1.22 g (7.00 mmol) of diethyl azodicarboxylate was added dropwise to the ice bath.After stirring for 1 hour in an ice bath, the reaction was carried out at room temperature until TLC followed the progress of the reaction.The solvent was evaporated under reduced pressure. EtOAc EtOAc m.The product was obtained as a reddish brown solid, 1.01 g, yield 58%.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazin-1(2H)-one

Reference£º
Patent; East China University of Science and Technology; Xu Xiaoyong; Li Zhong; Chen Xiulei; Li Wei; Jia Haowu; Cao Xiaofeng; Shao Xusheng; Xu Zhiping; (70 pag.)CN108276352; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazine,belong phthalazine compound

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weighing 2H-phthalazin-1-one (150 mmol), tert-butyl 5-({[(2-chlorophenyl)methoxy]carbonyl}amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate (195 mmol) in reaction bottle, adding DMF100ml, 55 C lower reaction overnight, stopping the reaction, by adding water 100 ml, dichloromethane 200 ml, extraction, separation of the organic phase, the aqueous phase to continue to dichloromethane is used for extraction (3 * 50 ml), the combined organic phase, anhydrous sodium sulfate drying, column chromatography purification obtained title compound.

119-39-1, 119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (11 pag.)CN109481444; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol., 253-52-1

As the paragraph descriping shows that 253-52-1 is playing an increasingly important role.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

It is a common heterocyclic compound, the phthalazine compound, Phthalazin-1(2H)-one, cas is 119-39-1 its synthesis route is as follows.,119-39-1

Weigh 2H-phthalazin-1-one (150 mmol),(3,4-Dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester-5-yl)-aminoO-chlorobenzyl formate (195 mmol) in a reaction flask,Add DMF100ml,The reaction was carried out at 55 C overnight.Stop the reaction,Add 100ml of water,200ml of dichloromethane,extraction,Separating the organic phase,The aqueous phase was further extracted with dichloromethane (3*50 ml).Combine the organic phase,Dry over anhydrous sodium sulfate,Purification by column chromatography gave the title compound.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazin-1(2H)-one

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (19 pag.)CN109180642; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

With the complex challenges of chemical substances, we look forward to future research findings about 253-52-1,belong phthalazine compound

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Phthalazin-1(2H)-one, cas is 119-39-1, it is a common heterocyclic compound, the phthalazine compound, its synthesis route is as follows.,119-39-1

Weighing 2H-phthalazin-1-one (150 mmol), tert-butyl 5-({[(2-chlorophenyl)methoxy]carbonyl}amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate (195 mmol) in reaction bottle, adding DMF100ml, 55 C lower reaction overnight, stopping the reaction, by adding water 100 ml, dichloromethane 200 ml, extraction, separation of the organic phase, the aqueous phase to continue to dichloromethane is used for extraction (3 * 50 ml), the combined organic phase, anhydrous sodium sulfate drying, column chromatography purification obtained title compound.

With the rapid development of chemical substances, we look forward to future research findings about Phthalazin-1(2H)-one

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (11 pag.)CN109481444; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, Phthalazine is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

253-52-1, The synthetic route of 253-52-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem