Month: September 2020

253-52-1, Phthalazine is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2.80 g (16.0 mmol) of 1-bromo-3-fluorobenzene, 25 mL of THF and 0.49 g (19.0 mmol) of magnesium metal was stirred vigorously at room temperature for 5 min and then refluxed for 1.5 h to give a yellow solution. Heating was discontinued, and a solution of 2.00 g (15.0 mmol) of 2 in 8 mL of THF was added dropwise with stirring over a period of 10 min. The reaction was then refluxed for 1 h and carried forward as in Method A (65 ¡ãC, 1 h) to give 1.63 g (38percent) of 6l as a viscous, brown oil., 253-52-1

253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Nammalwar, Baskar; Bunce, Richard A.; Berlin, K. Darrell; Bourne, Christina R.; Bourne, Philip C.; Barrow, Esther W.; Barrow, William W.; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 387 – 396;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, Phthalazine is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

253-52-1, 253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

261.3 mg of acetic anhydride copper (II) and Molecular Sieve 4A (79.1 mg) were added to 80.7 mg of the resin obtained in Process 4. 400.0 mg of 1(2H)-phthalazinone and 984 mul of diisopropylethylamine in a solution of NMP (4 ml) were further added therein and stirred at 50C for 23 hours. After removing the reaction solution, the resin was washed with DMF, water, ethanol and DCM three times each and dried under reduced pressure.

119-39-1, The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ajinomoto Co., Inc.; EP1454898; (2004); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: The reaction was carried out under argon. To a stirred suspension of sodium hydride (4.25 mol) in dry DMF (10 cm3) was added slowly a solution of 2H-phthalazin-1-one 2 (3.95¡Á10-3 mol) in dry DMF (50 cm3). The reaction mixture was stirred at room temperature for 45 minutes. Next, the whole lot was cooled to 0 C and the solution of N-(2-bromoethyl)phthalimide (5.92¡Á10-3 mol) in dry DMF (10 cm3) was added in portions. At first the mixture was kept for 5 hours in 0 C and later for 16 hours in ambient temperature. After this time the reaction mixture was poured into ice-water mixture (100 cm3) and next extracted with CHCl3 (3¡Á50 cm3). The combined extracts were dried over MgSO4 and concentrated under vacuum. The isoindole-1,3-dione 3 was isolated by column chromatography or crystallization.

119-39-1, 119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Malinowski, Zbigniew; Sroczy?ski, Dariusz; Szczes?niak, Aleksandra K.; Synthetic Communications; vol. 45; 15; (2015); p. 1743 – 1750;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a round bottom flask containing THF (10 mL) under an atmosphere of nitrogen was added, phthalazone (500 mg, 3.41 mmol), di-/c/ -butyl dicarbonate (1.11 g, 5.12 mmol) and DMAP (620 mg, 5.12 mmol). The reaction was stirred overnight at room temperature before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using -pentane: EtOAc (5: 1) tert- Butyl 1 -oxophthalazine-2( i H)- carboxylate as a white solid (765 mg, 3.11 mmol, 91%). 3H NMR (400 MHz, CDCb) d = 8.43 (dd, 7 = 7.9, 1.3 Hz, 1H), 7.83 (td, 7 = 7.5, 1.4 Hz, 1H), 7.77 (td, 7 = 7.6, 1.3 Hz, 1H), 7.68 (dd, 7 = 7.5, 1.3 Hz, 1H), 1.66 (s, 9H);13C NMR (100 MHz, CDCb) d = 158.3, 150.9, 138.9, 134.2, 132.3, 129.2, 128.7, 127.5, 126.4, 85.9, 27.8 (3C); IR (v, cm4): 2980, 1720, 1641, 1470, 1325, 1130; HRMS (ESI) for C13H14N2O3 (0556) [M+H]+ requires 247.1012 found 247.1015; Mp: 81 – 83C

119-39-1, The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The phthalazine compound, name is Phthalazine,cas is 253-52-1, mainly used in chemical industry, its synthesis route is as follows.,253-52-1

General procedure: (NH4)2C2O4¡¤H2O (0.085g, 0.60mmol) was dissolved in water (5ml) and slowly added to the methanolic solution of CuCl2¡¤2H2O (0.1g; 0.59mmol) and suitable N-donor ligand. The resulting solution was kept for evaporation at room temperature, and after a few days green crystals of 1, 2 and 3 were obtained, filtered off and dried in air.

As the rapid development of chemical substances, we look forward to future research findings about 253-52-1

Reference£º
Article; Machura; Switlicka-Olszewska; Kruszynski; Gron; Oboz; Duda; Polyhedron; vol. 62; (2013); p. 158 – 168;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, Phthalazine is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of sodium dicyanamide (0.11 g, 1.23 mmol) in water (10 ml) was slowly added to the methanolic solution (15 ml) of Cd(NO3)24H2O (0.2 g, 0.65 mmol and quinazoline (0.17 g, 1.30 mmol) and stirred at room temperature for 12 h. White crystalline precipitate of [Cd(Qnz)2(dca)2]n was collected in 70percent yield. The crystals suitable for X-ray structure determination were obtained by slow recrystallization from methanol

253-52-1, 253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Machura; Nawrot; Kruszynski; Dulski; Polyhedron; vol. 54; (2013); p. 272 – 284;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

253-52-1, The synthetic route of 253-52-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is 6-(tert-Butyl)-8-fluorophthalazin-1(2H)-one, and cas is 1242156-59-7, its synthesis route is as follows.,1242156-59-7

Step 2: 1-(3-Bromo-2-formylphenyl)-3-(4-(morpholine-4-carbonyl)phenylamino)-1H-pyrazole-4-carbonitrile (34 mg, 0.0708 mmol), 6-tert-butyl-8-fluorophthalazin-1(2H)-one (31.2 mg, 0.142 mmol), cuprous iodide (27 mg, 0.142 mmol) and sodium bicarbonate (14.9 mg, 0.177 mmol) were combined in 1 mL of DMSO. The solution was degassed with argon and then heated in a microwave at 120 C. for 1 hr. The resulting mixture was extracted with ethyl acetate and ammonium chloride solution. The organic layer was concentrated and purified by flash column chromatography using ethyl acetate (containing 5% methanol) in hexanes (5% to 80% linear gradient in 15 minutes, 12 g silica gel) to give the pure desired product. This material was triturated with ether in hexanes and filtered to give 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carbonitrile (18.2 mg, 41.5% yield) as a pale pink solid. LC/MS clacd for C33H30FN7O3 (m/e) 591.24, obsd 592.0 (M+H, ES+); 1H NMR (400 MHz, DMSO-d6) delta ppm 1.38 (s, 9H), 3.50 (br., 4H), 3.59 (br., 4H), 7.37 (d, J=8.6 Hz, 2H), 7.59 (d, J=8.3 Hz, 1H), 7.65-7.71 (m, 3H), 7.78 (d, J=13.1 Hz, 1H), 7.87-7.93 (m, 2H), 8.08 (s, 1H), 8.58 (d, J=2.3 Hz, 1H), 9.29 (s, 1H), 9.47 (s, 1H).

With the complex challenges of chemical substances, we look forward to future research findings about 1242156-59-7,belong phthalazine compound

Reference£º
Patent; Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta; US2012/295885; (2012); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, and cas is 763111-47-3, its synthesis route is as follows.,763111-47-3

General procedure: Compound 4 (400 mg, 1.09 mmol, 1 eq) was dissolved in acetonitrile(10 ml), and then 5a-c (1 eq) and DIEA (2 eq) were added.The mixture was stirred at room temperature for 2 h, and then theprecipitate was filtered, washed with water, acetonitrile and ethylether, and dried to give products 6a-c.

With the complex challenges of chemical substances, we look forward to future research findings about 763111-47-3,belong phthalazine compound

Reference£º
Article; Yuan, Zigao; Chen, Shaopeng; Sun, Qinsheng; Wang, Ning; Li, Dan; Miao, Shuangshuang; Gao, Chunmei; Chen, Yuzong; Tan, Chunyan; Jiang, Yuyang; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 4100 – 4109;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem