With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.
2H-phthalazin-1-one (150 mmol), (3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester-5-yl)-carbamic acid o-chlorophenyl ester (195 mmol) were placed in a reaction flask, then DMF100 ml was added and the reaction was carried out at 55 C overnight. The reaction was stopped, added 300 ml of ethyl acetate, 200ml of dichloromethane, and extracted. The organic phase was separated, and the aqueous phase was extracted with dichloromethane (3*50 ml). The organic phase was combined, dried over anhydrous sodium sulfate, and Purification by column chromatography gave the title compound.
119-39-1, As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.
Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (16 pag.)CN109336863; (2019); A;,
Phthalazine – Wikipedia
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