It is a common heterocyclic compound, the phthalazine compound, Phthalazin-1(2H)-one, cas is 119-39-1 its synthesis route is as follows.,119-39-1
To a round bottom flask containing THF (10 mL) under an atmosphere of nitrogen was added, phthalazone (500 mg, 3.41 mmol), di-/c/ -butyl dicarbonate (1.11 g, 5.12 mmol) and DMAP (620 mg, 5.12 mmol). The reaction was stirred overnight at room temperature before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using -pentane: EtOAc (5: 1) tert- Butyl 1 -oxophthalazine-2( i H)- carboxylate as a white solid (765 mg, 3.11 mmol, 91%). 3H NMR (400 MHz, CDCb) d = 8.43 (dd, 7 = 7.9, 1.3 Hz, 1H), 7.83 (td, 7 = 7.5, 1.4 Hz, 1H), 7.77 (td, 7 = 7.6, 1.3 Hz, 1H), 7.68 (dd, 7 = 7.5, 1.3 Hz, 1H), 1.66 (s, 9H);13C NMR (100 MHz, CDCb) d = 158.3, 150.9, 138.9, 134.2, 132.3, 129.2, 128.7, 127.5, 126.4, 85.9, 27.8 (3C); IR (v, cm4): 2980, 1720, 1641, 1470, 1325, 1130; HRMS (ESI) for C13H14N2O3 (0556) [M+H]+ requires 247.1012 found 247.1015; Mp: 81 – 83C
With the complex challenges of chemical substances, we look forward to future research findings about Phthalazin-1(2H)-one
Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
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