Month: October 2020

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stage A 2-{2-[(Tetrahydro-2-pyranyl)oxy]ethyl}-1-oxophthalazine A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated. Yield: 80% Proton nuclear magnetic resonance spectrum (400 MHz, solvent CDCl3): 1.3 to 2 ppm,m,6H; 3.3 to 4.8 ppm,m+m, 1H+6H; 7.6 to 7.9 ppm,m,3H; 8.15 ppm,s,1H; 8.4 ppm,m,1H, 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; Adir et Compagnie; US5077288; (1991); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong phthalazine compound,Phthalazine,253-52-1,Molecular formula: C8H6N2,mainly used in chemical industry, its synthesis route is as follows.,253-52-1

A solution of 3.0g (23.3mmol) of phthalazine in 20mL of concentrated sulfuric acid was brought to 100C. To the phthalazine solution was added portion-wise 18.8g (186mmol) of potassium nitrate over 1-h time period. After 72h at 100C, the solution was cooled to room temperature, poured over ice, and neutralized with ammonium hydroxide to produce a yellow-tan precipitate. The precipitate was collected and dried to afford 2.3g (56%) of the 5-nitrophthalazine intermediate as a light yellow solid. 1H NMR (400MHz, DMSO-d6) delta: 10.2 (s, 1 H), 9.98 (s, 1 H), 8.84 (d, J=7.4Hz, 1H), 8.59 (d, J=7.6Hz, 1H), 8.20 (dd, J=7.4, 14.9Hz, 1H). 13C NMR (100.17MHz, DMSO-d6) delta: 152.1, 146.3, 141.0, 133.2, 131.8, 130.0, 127.4, 118.7.

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazine,belong phthalazine compound

Reference£º
Article; Paige, Mikell; Kosturko, George; Bulut, Guellay; Miessau, Matthew; Rahim, Said; Toretsky, Jeffrey A.; Brown, Milton L.; Ueren, Aykut; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 478 – 487;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong phthalazine compound,Phthalazin-1(2H)-one,119-39-1,Molecular formula: C8H6N2O,mainly used in chemical industry, its synthesis route is as follows.,119-39-1

To a round bottom flask containing DMF (30 mL) under an atmosphere of nitrogen was added, phthalazone (500 mg, 3.42 mmol), anhydrous potassium carbonate (708 mg, 5.12 mmol) and allyl bromide (442 pL, 5.12 mmol). The reaction was stirred overnight at room temperature before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using n -pentane: EtOAc (3:1) affording 2-allylphthalazin- 1 (2/7)-onc as a brown oil (222 mg, 1.20 mmol, 35%) NMR (400 MHz, CDCb) d = 8.42 (ddd, J = 7.5, 1.7, 0.7 Hz, 1H), 8.17 (d, J = 0.8 Hz, 1H), 7.83 – 7.72 (m, 2H), 7.71 – 7.67 (m, 1H), 6.04 (ddt, / = 17.2, 10.3, 5.9 Hz, 1H), 5.30 – 5.22 (m, 2H), 4.85 (dt, J = 5.9, 1.5 Hz, 2H); 13C NMR (100 MHz, CDCb) d = 159.2, 138.1, 133.1, 132.5, 131.7, 129.7, 128.0, 126.8, 126.0, 118.0, 53.5. Data is in accordance with literature values (Nezhawy, A.O.H., Gaballah, S.T. & Radwan, M.A.A. Studying the reactivity of (phthalazin-l(2H)-on-2-yl)methyl trichloroacetimidate towards different C- and O-nucleophiles. Tetrahedron Letters 50, 6646-6650, 2009).

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazin-1(2H)-one,belong phthalazine compound

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.253-52-1,Phthalazine,as a common compound, the synthetic route is as follows.

28.1. Preparation of 1-furan-2-yl-1,2-dihydrophthalazine 22.5 ml of an about 1.6M solution of butyllithium are slowly added dropwise at -78¡ã C. to a solution of 2.46 g of furan in 30 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 20 min., then at -20¡ã C. for 2 hrs. The solution is again cooled to -78¡ã C. and treated slowly with a solution of 4.68 g of phthalazine in 36 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 2 hrs., then poured on to about 500 ml of ice-water and extracted 4 times with 150 ml of ethyl acetate each time. The organic phases are dried, concentrated and the residue is chromatographed immediately on 120 g of silica gel; eluent: hexane/ethyl acetate 3:7. 4.08 g of dark, impure 1-furan-2-yl-1,2-dihydrophthalazine are isolated. The following compounds of formula IV are prepared in analogy to Example 28.1.:, 253-52-1

253-52-1 Phthalazine 9207, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; Hoffmann-La Roche Inc.; US6114330; (2000); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong phthalazine compound,Phthalazin-1(2H)-one,119-39-1,Molecular formula: C8H6N2O,mainly used in chemical industry, its synthesis route is as follows.,119-39-1

The reaction was carried out in a round-bottom flask fitted with a magnetic stirrer bar. To a suspension of phthalazin-1(2H)-one (2) or 2-methylphthalazin-1(2H)-one (5) or pyridopyridazinone 8 (6.84mmol) in water (55mL) (Method A) or in the acetate buffer solution pH=5.8 (55mL) (Method B), was added potassium bromide (8.44mmol) and bromine (8.44mmol) at an ambient temperature. The mixture was then stirred for 6h at an ambient temperature, and next the whole was heated to boiling and stirred for 25h until the bromine colour entirely disappeared. After cooling to an ambient temperature (in the case of 9 the mixture was adjusted to pH 7 with saturated NaHCO3) the separated solid was collected by filtration and washed with water (5mL). The crude product was purified by flash chromatography. 4.4.1 4-Bromophthalazin-1(2H)-one (3) (Path A) White solid; Yield: 693 mg, 45% (Method A), 1.02 g, 66% (Method B); Mp: 279-281 C, (lit. 277-279 C;273 C ); Rf (DCM/AcOEt/Hex 6:1:1)=0.24; FTIR (KBr): nu=3022, 2931, 2892, 1671, 1659 (C=O), 1581 cm-1; 1H NMR (600 MHz, DMSO-d6): delta=12.94 (s, 1H, NH), 8.26 (d, J=7.9 Hz, 1H, 8 Ar-H), 8.06-8.01 (m, 1H, Ar-H), 7.97-7.91 (m, 2H, Ar-H); 13C NMR (150 MHz, DMSO-d6): delta=159.1 (C=O), 134.8, 133.1, 129.9, 129.4, 128.2, 127.6, 126.5 ppm; HRMS (ESI) m/z: calcd for C8H6BrN2O [M+H]+ 224.9658, found 224.9658.

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazin-1(2H)-one,belong phthalazine compound

Reference£º
Article; Malinowski, Zbigniew; Fornal, Emilia; Sieroci?ska, Beata; Czeczko, Renata; Nowak, Monika; Tetrahedron; vol. 72; 49; (2016); p. 7942 – 7951;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the commercially available phthalazin-l(2//)-one (5.0 g, 34.0 mmol) and phosphorus oxychloride (POCh) (25 mL) was heated with stirring at l00C for 2 h. After cooling to room temperature, the excess POCI3 was completely distilled out under reduced pressure. The residue was triturated with toluene (2 x 25 mL) and followed with THF (100 mL), and the solid product was collected by filtration and washed with THF. The product was then dissolved in DCM, washed with saturated aqueous NaHC03 solution, dried over sodium sulfate and evaporated under reduced pressure to give 1- chlorophthalazine. Yield 4.6 g (82%); mp 119-121 C (lit.33 mp 132-134 C). (0220) [0134] NMR (DMSO-^e) d 8.20 (2H, t, J = 7.2 Hz, ArH), 8.33 (2H, t, J = 7.6 Hz, ArH), 9.73 (1H, s, ArH). (0221) [0135] 13C NMR (DMSO-?) d 126.1, 128.4, 128.7, 155.3. HRMS [ESL]: calculated for C8H5ClN2, 165.0220 [M+H]+, found 165.0212., 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; ACADEMIA SINICA; SU, Tsann-long; LEE, Te-chang; CHEN, Tai-lin; (92 pag.)WO2019/99755; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

2H-phthalazin-1-one (150 mmol), (3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester-5-yl)-carbamic acid o-chlorophenyl ester (195 mmol) were placed in a reaction flask, then DMF100 ml was added and the reaction was carried out at 55 C overnight. The reaction was stopped, added 300 ml of ethyl acetate, 200ml of dichloromethane, and extracted. The organic phase was separated, and the aqueous phase was extracted with dichloromethane (3*50 ml). The organic phase was combined, dried over anhydrous sodium sulfate, and Purification by column chromatography gave the title compound.

119-39-1, As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (16 pag.)CN109336863; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Phthalazin-1(2H)-one (7 mmol) and POCl3 (56 mmol) were charged into a 100-mL, 3-necked flask and heated at 75C for 30 min. After being cooled to room temperature, the mixture was poured into ice water and then added additional 10% NaOH until the pH of the solution is 7.5. The solid was isolated by filtration and washed with 2 ml iced water. The resulting solid was dissolved in EtOH (6 ml), to which 50% hydrazine hydrate (3 ml) was added. After stirring at 60-70C for 2h, the pH value of the mixture was adjusted to 3 with 15% hydrochloric acid. Then the mixture was cooled to 0-5C. The solid was isolated by filtration, washed with iced EtOH (2 ml), and dried, giving the desired product (894 mg, 65% yield)., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhang, Chunlei; Zhou, Xigeng; Tetrahedron; vol. 72; 50; (2016); p. 8282 – 8286;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazin-1(2H)-one, and cas is 119-39-1, its synthesis route is as follows.,119-39-1

General procedure: Anhydrous potassium carbonate (0.009 mol) was added to appropriate 1(2H)-phthalazinone derivative (0.003 mol) in 7 mL of anhydrous DMF. Subsequently, 1-bromo-2-chloroethane (0.009 mol) was added to this solution and reaction mixture was stirred at room temperature for 2.5 h. Then, the reaction mixture was poured into ice water and the precipitate was filtered to yield compound (4, 5 and 6), which was used for the next step without further purification. 2-(2-Chloroethyl)phthalazin-1(2H)-one (4). White solid, mp 98-101C, ESI-HRMS m/z: Calcd. for C10H10ClN2O (MH+), 209.0482, found 209.0472.

With the complex challenges of chemical substances, we look forward to future research findings about 119-39-1,belong phthalazine compound

Reference£º
Article; Kilic, Burcu; Guelcan, Hayrettin Ozan; Yalcin, Mertcan; Aksakal, Fatma; Dimoglo, Anatoli; ?ahin, Mustafa Fethi; Do?ruer, Deniz Songuel; Letters in drug design and discovery; vol. 14; 2; (2017); p. 159 – 166;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.,253-52-1

Example 1A1,2-phenylenedimethanamine[0168]Phthalazine (21.5 g, 0.165 mol), 10percent palladium on carbon (2 g), and methanol (125 mL) were combined in a pressure bottle and shaken at room temperature under 60 psi of hydrogen for 5 days. Raney-nickel? slurry (6.42 g) and 10percent palladium on carbon (0.50 g) were added, and the mixture was shaken at 50¡ã C. under 60 psi of hydrogen for 16 hours. The mixture was filtered through a nylon membrane and concentrated to give the titled compound: 1H NMR (300 MHz, DMSO-d6) delta ppm 7.32 (dd, J=5.4, 3.5 Hz, 2H), 7.17 (dd, J=5.6, 3.4 Hz, 2H), 3.74 (s, 4H); MS (DCI/NH3) m/z 137 (M+H)+.

With the complex challenges of chemical substances, we look forward to future research findings about Phthalazine

Reference£º
Patent; AbbVie Inc.; Cowart, Marlon D.; Liu, Huaqing; Altenbach, Robert; US2013/40940; (2013); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem