As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazin-1(2H)-one, and cas is 119-39-1, its synthesis route is as follows.
To a round bottom flask containing DMF (30 mL) under an atmosphere of nitrogen was added, phthalazone (500 mg, 3.42 mmol), anhydrous potassium carbonate (708 mg, 5.12 mmol) and allyl bromide (442 pL, 5.12 mmol). The reaction was stirred overnight at room temperature before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using n -pentane: EtOAc (3:1) affording 2-allylphthalazin- 1 (2/7)-onc as a brown oil (222 mg, 1.20 mmol, 35%) NMR (400 MHz, CDCb) d = 8.42 (ddd, J = 7.5, 1.7, 0.7 Hz, 1H), 8.17 (d, J = 0.8 Hz, 1H), 7.83 – 7.72 (m, 2H), 7.71 – 7.67 (m, 1H), 6.04 (ddt, / = 17.2, 10.3, 5.9 Hz, 1H), 5.30 – 5.22 (m, 2H), 4.85 (dt, J = 5.9, 1.5 Hz, 2H); 13C NMR (100 MHz, CDCb) d = 159.2, 138.1, 133.1, 132.5, 131.7, 129.7, 128.0, 126.8, 126.0, 118.0, 53.5. Data is in accordance with literature values (Nezhawy, A.O.H., Gaballah, S.T. & Radwan, M.A.A. Studying the reactivity of (phthalazin-l(2H)-on-2-yl)methyl trichloroacetimidate towards different C- and O-nucleophiles. Tetrahedron Letters 50, 6646-6650, 2009).
119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
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