Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.
To a stirred solution of 1-methylindole (1.50 g, 11.4 mmol) in dry THF (25 mL) was added dropwise n-BuLi (6.86 mL,17.2 mmol, 2.5 M in hexanes) over a period of 30 min at ?78 ¡ãC. The solution was warmed to ?25 ¡ãC, and stirring was continued at this temperature for 1 h. The reaction mixture was cooled to ?78 ¡ãC, and a solution of 4 (1.48 g, 11.4 mmol) in dry THF (20 mL) was added dropwise over 30 min. The reaction mixture was stirred at this temperature for 2 h. The mixture was poured into saturated NH4Cl (100 mL) and extracted with EtOAc (3 ¡Á 50 mL). The combined organic extracts were washed with saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated under vacuum to give 5l as a light yellow liquid. The crude product 5l was dissolved in DCM (100 mL), and TEA (2.08 g, 2.87 mL, 20.6 mmol) was added, followed by dropwise addition of acryloyl chloride (0.81 g, 0.73 mL, 8.95 mmol) at 0 ¡ãC. The reaction mixture was stirred at this temperature for an additional 2 h. The aqueous layer was added to saturated NaCl (50 mL), and the organic layer was separated. The aqueous layer was extracted with DCM (2 ¡Á 30 mL), and the combined organic extracts were washed with saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated to afford the crude product. The product was purified on a silica gel column eluted with hexanes?EtOAc (7:3) to afford 2l (3.01 g, 62percent) as a light yellow solid
253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see
Reference£º
Article; Muddala, Nagendra Prasad; Nammalwar, Baskar; Selvaraju, Subhashini; Bourne, Christina R.; Henry, Mary; Bunce, Richard A.; Berlin, K. Darrell; Barrow, Esther W.; Barrow, William W.; Molecules; vol. 20; 4; (2015); p. 7222 – 7244;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem