In the next few decades, the world population will flourish. 119-39-1.As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.
Weigh 0.324g of commercial compound C1a dissolved in 3ml DMF,60% NaH 0.16g was added under ice bath.Stir for 30 minutes and add 0.591 g of ethyl 4-(bromomethyl)benzoate.Stir for 1 hour at room temperature. Pour the reaction mixture into 100ml of crushed ice.Extract several times with ethyl acetate, combine the organic layers, and evaporate.Light yellow solid (Intermediate C1b).Dissolve this intermediate in 10 ml of THF and add 2.9 ml of 8N NaOH.Return overnight. The reaction solution was diluted with water, and the aqueous layer was washed with ethyl acetate.The aqueous layer was adjusted to pH 6 with 6N HCl, precipitated and filtered.The precipitate is washed with water and dried to give a beige product C1c
119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem