119-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Anhydrous potassium carbonate (0.009 mol) was added to appropriate 1(2H)-phthalazinone derivative (0.003 mol) in 7 mL of anhydrous DMF. Subsequently, 1-bromo-2-chloroethane (0.009 mol) was added to this solution and reaction mixture was stirred at room temperature for 2.5 h. Then, the reaction mixture was poured into ice water and the precipitate was filtered to yield compound (4, 5 and 6), which was used for the next step without further purification. 2-(2-Chloroethyl)phthalazin-1(2H)-one (4). White solid, mp 98-101C, ESI-HRMS m/z: Calcd. for C10H10ClN2O (MH+), 209.0482, found 209.0472.
Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase., 119-39-1
Reference£º
Article; Kilic, Burcu; Guelcan, Hayrettin Ozan; Yalcin, Mertcan; Aksakal, Fatma; Dimoglo, Anatoli; ?ahin, Mustafa Fethi; Do?ruer, Deniz Songuel; Letters in drug design and discovery; vol. 14; 2; (2017); p. 159 – 166;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem