The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazine, cas is 253-52-1,the phthalazine compound. A new synthetic method of this compound is introduced below. 253-52-1
General procedure: A solution of 2.00 g (15.0 mmol) of 2 in 20 mL of dry THF was cooled to 0 ¡ãC, and 8.0 mL of 2.0 M isopropylmagnesium chloride (3b) (16.0 mmol) in ether was slowly added dropwise over 20 min. The reaction was allowed to stir at 0 ¡ãC for 5 h and was then quenched with 50 mL of saturated NH4Cl and extracted with ethyl acetate (3 .x. 50 mL). The combined organic extracts were washed with saturated NaCl, dried (MgSO4), and concentrated under vacuum to give dihydrophthalazine 4b as a viscous, brown oil. This oil was dried under high vacuum for 30 min and was used without further purification.The crude 4b in dichloromethane at 0 ¡ãC was treated, as above, with 1.82 g (2.50 mL, 18.0 mmol) of triethylamine and 1.40 g (1.26 mL, 15.5 mmol) of 5, and the reaction was stirred for 2 h. Work-up and chromatography gave 1.83 g (40percent) of 6b as a viscous, brown oil.
The chemical industry reduces the impact on the environment during synthesis,253-52-1,Phthalazine,I believe this compound will play a more active role in future production and life.
Reference£º
Article; Nammalwar, Baskar; Bunce, Richard A.; Berlin, K. Darrell; Bourne, Christina R.; Bourne, Philip C.; Barrow, Esther W.; Barrow, William W.; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 387 – 396;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem