A new application about 53242-88-9

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An article , which mentions 53242-88-9, molecular formula is C15H11ClN2O. The compound – 4-(4-Chlorobenzyl)phthalazin-1(2H)-one played an important role in people’s production and life., 53242-88-9

The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds

The in vitro antiplasmodial activity of some dihydrostilbenamides, phtalazinones, imidazo[2,1-a]isoindole and pyrimido[2,1-a]isoindole derivatives related to the natural dihydrostilbenoid isonotholaenic acid is reported. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum and potent representative compounds were also evaluated in the ferriprotoporphyrin IX biomineralization inhibition test (FBIT). Compounds having the imidazo[2,1-a]isoindole skeleton were the most active and one compound of this group resulted to be as potent as chloroquine, but acting through a mechanism different that of the inhibition of heme biomineralization.

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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N723 – PubChem