Month: November 2020

It is a common heterocyclic compound, the phthalazine compound, 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid, cas is 42972-13-4 its synthesis route is as follows.

Bromo-4-oxo-3,4-dihydro–phthalazine-6-carboxylic acid: 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid (91.0 g, 0.44 mol) was suspended in DCE (1.0 L) and phosphorus pentabromide (761.0 g, 1.77 mol) was added in three portions and the reaction heated to reflux for 24 hours. The reaction was cooled to RT and poured onto ice (2.50 kg) and the resulting precipitate filtered and washed with water to give the crude product (130 g).

42972-13-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,42972-13-4 ,1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Roche Palo Alto LLC; US2007/219195; (2007); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

1242156-59-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-(tert-Butyl)-8-fluorophthalazin-1(2H)-one, cas is 1242156-59-7,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

To a stirred suspension of NaH (60%, 55 mg, 1.36 mmol) in DMF (5 mL) was added dropwise a solution of 6-tert-butyl-8-fluoro-2H-phthalazin-l-one (which may be prepared as described in Berthel, S. et al. US 20100222325 Column 139; 150.0 mg, 0.68 mmol) in DMF (10 mL) at 0 C. The mixture was heated to 70 C and stirred for 30 min. The mixture was cooled to room temperature, a solution of 4-bromo-l-chloromethyl-2-fluoro-benzene (available from Aldrich; 167.3 mg, 0.75 mmol) in DMF (5 mL) was added and the mixture was stirred for 4 h at room temperature. Aqueous NH4C1 solution was added. The mixture was extracted with EtOAc, and the EtOAc extract was dried, and evaporated. The residue was purified by chromatography (silica gel, 5% EtOAc/hexane) to give 2-(4-bromo-2-fluoro-benzyl)-6-tert-butyl-8-fluoro-2H- phthalazin-l-one (160 mg, 58%) as a white solid. MS calcd. for Ci9Hi8BrF2N20 [(M+H)+] 408, obsd. 408.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6-(tert-Butyl)-8-fluorophthalazin-1(2H)-one, 1242156-59-7

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DOMINIQUE, Romyr; LOPEZ-TAPIA, Francisco Javier; MERTZ, Eric; SO, Sung-Sau; WO2014/76104; (2014); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

Weigh 2H-phthalazin-1-one (150 mmol),(3,4-Dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester-5-yl)-aminoO-chlorobenzyl formate (195 mmol) in a reaction flask,Add DMF100ml,The reaction was carried out at 55 C overnight.Stop the reaction,Add 100ml of water,200ml of dichloromethane,extraction,Separating the organic phase,The aqueous phase was further extracted with dichloromethane (3*50 ml).Combine the organic phase,Dry over anhydrous sodium sulfate,Purification by column chromatography gave the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazin-1(2H)-one, 119-39-1

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (19 pag.)CN109180642; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

763111-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, cas is 763111-47-3,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Intermediates 8 (1 eq) and respective 9-chloroacridine derivatives 4a-4f (1.1 eq) were added to a round flask, and then excessphenol was added as solvent. The reaction system was warmed up to 60 C until phenol was melted and stirred for 0.5 h under argonprotection. Then the mixture was warmed up to 120 C and continued to reaction for more 2 h. After the reaction was completed, themixture was added to ethyl ether drop by drop [2]. The precipitate was filtered and washed twice with new ethyl ether to give pureproducts 9a-9f, which were then characterized by 1H NMR, 13C NMR, melting point and high resolution mass spectrum (HRMS, ESI).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, 763111-47-3

Reference£º
Article; Dai, Qiuzi; Chen, Jiwei; Gao, Chunmei; Sun, Qinsheng; Yuan, Zigao; Jiang, Yuyang; Chinese Chemical Letters; vol. 31; 2; (2020); p. 404 – 408;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazin-1(2H)-one, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 119-39-1, its synthesis route is as follows.

General procedure: The reaction was carried out under argon. To a stirred suspension of sodium hydride (4.25 mol) in dry DMF (10 cm3) was added slowly a solution of 2H-phthalazin-1-one 2 (3.95¡Á10-3 mol) in dry DMF (50 cm3). The reaction mixture was stirred at room temperature for 45 minutes. Next, the whole lot was cooled to 0 C and the solution of N-(2-bromoethyl)phthalimide (5.92¡Á10-3 mol) in dry DMF (10 cm3) was added in portions. At first the mixture was kept for 5 hours in 0 C and later for 16 hours in ambient temperature. After this time the reaction mixture was poured into ice-water mixture (100 cm3) and next extracted with CHCl3 (3¡Á50 cm3). The combined extracts were dried over MgSO4 and concentrated under vacuum. The isoindole-1,3-dione 3 was isolated by column chromatography or crystallization.

119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Malinowski, Zbigniew; Sroczy?ski, Dariusz; Szczes?niak, Aleksandra K.; Synthetic Communications; vol. 45; 15; (2015); p. 1743 – 1750;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is 6-Bromophthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 19064-74-5, its synthesis route is as follows.

Example 154 Synthesis of 5′-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-3-fluoro-2′-(phthalazin-6-yl)-[1,1′-biphenyl]-4-carbonitrile The procedure of steps 1 to 5 in Example 41 was conducted using 6-bromophthalazine instead of 1-(4-bromo-3-fluoro-phenyl)-2-methyl-propan-2-ol to give the title compound.

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; OSADA, Akiko; EP3632443; (2020); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is 5-Nitrophthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 89898-86-2, its synthesis route is as follows.

(C) Phthalazine-5,8-dione precursors (Y1 and Y4=C, Y2 and Y3=N) used in the process of the present invention were prepared according to the following reaction scheme 4. The detailed procedure is described in (i) J. Med. Chem., 48, 744-752, and (ii) Bioorganic and Medical Chemistry Letters, 27, 2577-2580.

89898-86-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,89898-86-2 ,5-Nitrophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Gerogetown University; Brown, Milton L.; Paige, Mikell; Torestsky, Jeffrey A.; Uren, Aykut; Kosturko, George; Bulut, Gullay; (58 pag.)US9522908; (2016); B2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

763111-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, cas is 763111-47-3,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

4-(4-Fluoro-3-(piperazin-1-yl-carbonyl)-benzyl)pyridazine-1(2H)one (5) (1.56 g, 4.26 mmol) was added to a 25 ml three-necked flask.And added dichloromethane (6.5 ml), trans-4-dimethylamino crotonic acid (0.78 g, 6.04 mmol),HOBT (0.87 g, 6.44 mmol), EDCI (1.23 g, 6.42 mmol), and then cooled to 0-10 C, then DIPEA (4.42 g, 34.3 mmol) was added dropwise, and the mixture was allowed to warm to room temperature and stirred for 2 h.After TLC showed that the reaction was completed, the reaction mixture was quenched with water (30 mL).The solid crude product was added to the acid water, the impurities were extracted with dichloromethane, the aqueous phase was made alkaline, and the product was extracted with dichloromethane (20 mL¡Á3);The combined organic phases were dried over anhydrous sodium sulfate, filtered and evaporatedThe white solid product was then beaten with n-hexane (5 ml).Filter and dry to give 470 mg of a white solid.The yield was 23%.

The chemical industry reduces the impact on the environment during synthesis,763111-47-3,4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Shanghai Bobang Pharmaceutical Technology Co., Ltd.; Gao Heyong; Liu Zhende; Zhang Wensheng; (28 pag.)CN108383798; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.

To a stirred solution of 1-methylindole (1.50 g, 11.4 mmol) in dry THF (25 mL) was added dropwise n-BuLi (6.86 mL,17.2 mmol, 2.5 M in hexanes) over a period of 30 min at ?78 ¡ãC. The solution was warmed to ?25 ¡ãC, and stirring was continued at this temperature for 1 h. The reaction mixture was cooled to ?78 ¡ãC, and a solution of 4 (1.48 g, 11.4 mmol) in dry THF (20 mL) was added dropwise over 30 min. The reaction mixture was stirred at this temperature for 2 h. The mixture was poured into saturated NH4Cl (100 mL) and extracted with EtOAc (3 ¡Á 50 mL). The combined organic extracts were washed with saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated under vacuum to give 5l as a light yellow liquid. The crude product 5l was dissolved in DCM (100 mL), and TEA (2.08 g, 2.87 mL, 20.6 mmol) was added, followed by dropwise addition of acryloyl chloride (0.81 g, 0.73 mL, 8.95 mmol) at 0 ¡ãC. The reaction mixture was stirred at this temperature for an additional 2 h. The aqueous layer was added to saturated NaCl (50 mL), and the organic layer was separated. The aqueous layer was extracted with DCM (2 ¡Á 30 mL), and the combined organic extracts were washed with saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated to afford the crude product. The product was purified on a silica gel column eluted with hexanes?EtOAc (7:3) to afford 2l (3.01 g, 62percent) as a light yellow solid

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Muddala, Nagendra Prasad; Nammalwar, Baskar; Selvaraju, Subhashini; Bourne, Christina R.; Henry, Mary; Bunce, Richard A.; Berlin, K. Darrell; Barrow, Esther W.; Barrow, William W.; Molecules; vol. 20; 4; (2015); p. 7222 – 7244;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem