In an article, published in an article,authors is Beedham, Christine, once mentioned the application of 253-52-1, Name is Phthalazine,molecular formula is C8H6N2, is a conventional compound. this article was the specific content is as follows. 253-52-1
Aldehyde oxidase; new approaches to old problems
Despite expanding knowledge on the structure and reactivity of human aldehyde oxidase (hAOX1) many drugs enter human studies only to be removed from further clinical trials due to aldehyde oxidase (AOX)-catalysed metabolism. In addition to oxidation of numerous N-heterocycles and aldehydes, hAOX1 is also important in amide hydrolysis and reductive reactions. This article reviews the evidence for hAOX1 polymorphism and other genetic factors which affect hAOX1 expression and which may lead to attenuated drug metabolism. Difficulties in the selection of appropriate in silico and in vitro models for predicting hAOX1 metabolism are considered in the context of its wide substrate specificity.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N63 – PubChem