One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 53242-88-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 53242-88-9, Name is 4-(4-Chlorobenzyl)phthalazin-1(2H)-one, molecular formula is C15H11ClN2O
Anti-HIV activity of stilbene-related heterocyclic compounds
Viral transcription has not been routinely targeted in the development of new antiviral drugs. This crucial step of the viral cycle depends on the concerted action of cellular and viral proteins such as NF-kappaB and Tat. In the present study, stilbene-related heterocyclic compounds including benzalphthalide, phthalazinone, imidazoindole and pyrimidoisoindole derivatives are tested for their anti-HIV activity. Original assays based on recombinant viruses were used to evaluate HIV replication inhibition and stably transfected cell lines were used to evaluate inhibition of Tat and NF-kappaB proteins. Some of the stilbene-related heterocyclic compounds analysed displayed anti-HIV activity through interference with NF-kappaB and Tat function. Moreover, compounds inhibiting both targets displayed a stronger activity on viral replication.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N721 – PubChem