Month: December 2020

Related Products of 253-52-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 253-52-1, Phthalazine, introducing its new discovery.

SULFUR CONTAINING DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS

Substituted dihydrophthalazine sulfur containing compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with excessive activation of the non-NMDA subtype of the ionotropic EAA receptor. The compounds further are useful as testing agents to identify and characterize other compounds for the treatment of these disorders. The compounds are useful therapeutically as sedatives or for the treatment of neurosychopharmacological disorders such as stroke, ischemia and epilepsy. The compositions may be provided in combination with a suitable carrier for oral or parenteral administration. The compounds may be administered orally or parenterally for the treatment of a variety of disorders associated with non-NMDA EEA receptor function.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 253-52-1. In my other articles, you can also check out more blogs about 253-52-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N13 – PubChem

Electric Literature of 253-52-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a Article£¬once mentioned of 253-52-1

One pot synthesis of pyrazolo phthalazine dione derivatives under microwave irradiation

In this method, we have reported the catalytic ability of boric acid as a green, eco-friendly catalyst for one-pot four component condensation reaction of phthalic anhydride, Monohydrate hydrazine, Malononitrile and substituted aromatic aldehyde was reported. The major synthetic protocol is the use of inexpensive, nontoxic, avoiding the use of harmful organic solvent, short reaction time, mild condition reaction, simple procedure, excellent yield and environmentally benign.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 253-52-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N239 – PubChem

Related Products of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

A PARP inhibitor, its pharmaceutical composition, preparation method and application (by machine translation)

The invention provides a PARP inhibitor, its pharmaceutical composition, preparation method and application, which belongs to the field of medicine. The PARP inhibitor, its pharmaceutically acceptable salt, hydrate, solvate, metabolic precursor or prodrug of formula (I) is shown. The preparation method comprises: in an inert solvent, of formula (a) compound of the formula (b) compound in the presence of condensing agent and alkaline reagent under, the reaction is carried out, to obtain states the type (I) compounds. In addition also discloses a formula (I) indicated by the PARP inhibitor, its pharmaceutically acceptable salt, hydrate, solvate, metabolic precursor or prodrug in preparation for preventing or treating tumor application of the medicament. The present invention provides this kind of PARP inhibitor has excellent anti-PARP activity, can be used for preparing a plurality of anti-tumor pharmaceutical preparations (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Related Products of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N773 – PubChem

253-52-1, Name is Phthalazine, belongs to phthalazine compound, is a common compound. Computed Properties of C8H6N2In an article, once mentioned the new application about 253-52-1.

N-Chlorination-induced, oxidative ring contraction of 1,4-dimethoxyphthalazines

A rarely explored oxidative ring contraction of electron-rich 1,2-diazine is described. Upon treatment with an electrophilic chlorinating reagent (TCICA), 1,4-dimethoxyphthalazines undergo an N-chlorination-induced ring contraction that is accompanied by the loss of one nitrogen atom. The scope of this unusual reactivity was examined with a range of 1,4-dimethoxyphthalazine derivatives. In addition, a mechanism proceeding via a bicyclic species was proposed on the basis of an isolated reaction intermediate and DFT calculations.

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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N198 – PubChem

Synthetic Route of 253-52-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a Article£¬once mentioned of 253-52-1

NOUVEAUX DERIVES PYRIDAZINIQUES ET PHTALAZINIQUES DOUES D’ACTIVITE PHYSIOLOGIQUE

This paper reports eleven new pyridazines and phthalazines derivatives. Products 5-11 have been obtained starting from 3-chloro-6-hydrazino-pyridazine (4), by means of various reactions. Products 14-16 belong to the class of phthalazinium-ylids. The biological tests have shown the antimicrobial activity of products 14, 15 and 16. For the other products biological tests are still under way.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 253-52-1. In my other articles, you can also check out more blogs about 253-52-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N99 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H6N2. Introducing a new discovery about 253-52-1, Name is Phthalazine

External Heavy Atom Effect on Intersystem Crossing of Radical Pair in Solvent Cage. Photoreactions of Phthalazine

External heavy atom effects have been studied for the photoreaction of phthalazine in 2-propanol.Addition of bromine containing compounds alters the product distribution in the dual photoreactions occured simultaneously.The results can be interpreted in terms of enhancement of the intersystem crossing from the triplet radical pair to the singlet radical pair, including the spin inversion within the solvent cage.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C8H6N2, you can also check out more blogs about253-52-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N200 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Phthalazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 253-52-1, Name is Phthalazine, molecular formula is C8H6N2

Synthesis, spectral characterization and antimicrobial studies of new hybrid heterocyclic compounds bearing 1H-benzimidazol-2-yl thiomethyl motif

To understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-Aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Phthalazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 253-52-1, in my other articles.

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N123 – PubChem

763111-47-3, Name is 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, belongs to phthalazine compound, is a common compound. Quality Control of 4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-oneIn an article, once mentioned the new application about 763111-47-3.

Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma

Poly(ADP-ribose) polymerase (PARP) has emerged as an important molecular target for the treatment of several oncological diseases. A couple of molecular probes based on Olaparib scaffold have been developed by incorporation of F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor. PARP has been reported overexpressed in mesothelioma. We hereby synthesized an analogue of Olaparib containing DOTA moiety and radiolabeled it with Cu-64 to evaluate its utility of PET tracer for mesothelioma. The Cu-64 labeling was conveniently achieved at 90% yield with final compound at >99% radiochemistry purity. The biodistribution and PET imaging were performed at 0.5, 1, 2 and 18?h to confirm the in vivo tumor targeting. The tumor uptake in study group was significant higher than that in control group (3.45?¡À?0.47% ID/g vs 2.26?¡À?0.30% ID/g) and tumor were clearly detected by PET imaging. These results suggest the feasibility to develop an Olaparib-based theranostic agent for mesothelioma.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N820 – PubChem

3682-14-2, Name is 6-Amino-2,3-dihydrophthalazine-1,4-dione, belongs to phthalazine compound, is a common compound. COA of Formula: C8H7N3O2In an article, once mentioned the new application about 3682-14-2.

Chemiluminescence properties of luminol related o-hydroxybenzimidazole analogues: Experimental and DFT based approach to photophysical properties

Novel luminol-isoluminol derivatives containing o-hydroxyphenyl benzimidazole unit were synthesized from aromatic aldehydes and diaminophthalates followed by heating under reflux with hydrazine hydrate. The chemiluminescent properties were studied in hydrogen peroxide, potassium hexacyanoferrate(III) and sodium hydroxide solution. The chemiluminescence properties were compared with the standard luminol and isoluminol systems it was observed that the chemiluminescence properties of the novel derivatives were superior to luminol and isoluminol. Density Functional Theory computations have been used in order to have a greater understanding of the structural, molecular, electronic and photophysical properties. The experimental absorption and emission wavelength values were in good agreement with the computed vertical excitation and emission values.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N547 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 72702-95-5, name is 2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid, introducing its new discovery. HPLC of Formula: C17H12BrFN2O3

Synthesis and antimycobacterial evaluation of novel phthalazin-4- ylacetamides against log- and starved phase cultures: Research article

Twenty four novel 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1- phthalazinyl]acetic acid amides were synthesized from phthalic anhydride and were subjected to in vitro and in vivo evaluation against log- and starved phase of mycobacterial species and Mycobacterium tuberculosis isocitrate lyase enzyme inhibition studies. Among the compounds screened, 2-(2-(4-bromo-2-fluorobenzyl) -1,2-dihydro-1-oxophthalazin-4-yl)-N-(2,6-dimethylphenyl)acetamide (5j) inhibited all eight mycobacterial species with MIC’s ranging from 0.08 to 5.05 mum and was non-toxic to Vero cells till 126.43 mum. Four compounds were tested against starved culture of Mycobacterium tuberculosis and they inhibited with MIC’s ranging from 3.78 to 23.2 mum. Some compounds showed 40-66% inhibition against Mycobacterium tuberculosis isocitrate lyase enzyme at 10 mum. The docking studies also confirmed the binding potential of the compounds at the isocitrate lyase active site. In the in vivo animal model, 5j reduced the mycobacterial load in lung and spleen tissues with 1.38 and 2.9-log10 protections, respectively, at 25 mg/kg body weight dose.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 72702-95-5, and how the biochemistry of the body works.HPLC of Formula: C17H12BrFN2O3

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N917 – PubChem