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Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction
Background Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases. Results and conclusion The tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66-753 muM. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N141 – PubChem