Application of 253-52-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a article£¬once mentioned of 253-52-1
Synthesis, Structure, and Biological Activity of New Azine-Bridged Dinuclear Platinum(II) Complexes – A New Class of Anticancer Compounds
A recently described new class of dinuclear platinum anticancer compounds, represented so far by the isomeric azine-bridged complexes [{cis-Pt(NH 3)2Cl}2(mu-pzn)]Cl2 (1) (pzn = pyrazine), [{cis-Pt(NH3)2Cl)2(mu-pmn)]Cl 2 (2) (pmn = pyrimidine) and [{cis-Pt(NH3) 2Cl}2(mu-pdn)](NO3)2 (3) (pdn = pyridazine), has been added to. Three new dinuclear complexes of this type, [{cis-Pt(NH3)2Cl}2(mu-2,5pzn)]Cl2 (4) (2,5pzn = 2,5-dimethylpyrazine), [{cis-Pt(NH3) 2Cl)2(mu-qzn)]Cl2 (5) (qzn = quinazoline), and [{cis-Pt(NH3)2Cl}2(mu-pht)](NO 3)2 (6) (pht = phthalazine), have been newly synthesized and characterized by 1H and 195Pt NMR spectroscopy. The interaction of the new compounds with 2 equiv. of 9EtG in D2O at 310 K has been investigated. Complexes 4 and 5 undergo substitution of both chloride ligands by 9EtG similarly to the related complexes 1 and 2, respectively. The methyl substituents on the pyrazine ring induce steric hindrance in 4 resulting in a slower reaction rate as compared to 1. Similarly to the case of 3, interaction of complex 6 with 9EtG results in cleavage of the Pt-N(pht) bond and subsequent formation of the polymeric species. A cytotoxicity assay of 4-6 has been performed on seven human tumor cell lines and on L1210 murine leukemia cell lines, sensitive and resistant to cisplatin. Compounds 4 and 5 exhibit lower cytotoxicity than the analogous complexes with unsubstituted azines. Complex 6 is more active: its cytotoxicity in the L1210 cell lines is similar to that of cisplatin. Analysis of nuclear DNA fragmentation in L1210 cells treated with the azine-bridged complexes 1-6 has been carried out. The results clearly indicate induction of apoptosis by all the compounds, implying considerable anticancer potential. The structure-activity relationship for this class of dinuclear platinum(ii) complexes is discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N218 – PubChem