Application of 253-52-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 253-52-1, molcular formula is C8H6N2, introducing its new discovery.
Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives
In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl) thio) acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl) piperazin-1-yl) acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mumol?L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 253-52-1 is helpful to your research. Application of 253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N484 – PubChem