Related Products of 253-52-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.253-52-1, Name is Phthalazine, molecular formula is C8H6N2. In a Article£¬once mentioned of 253-52-1
Benzoquinolines and chloride secretion in murine colonic epithelium
1. In all, 27 compounds related chemically to phenanthrolines were investigated for their ability to stimulate electrogenic chloride secretion in murine colonic epithelia under short circuit current conditions. A total of 11 compounds, not previously examined, were shown to have substantial activity. Cumulative concentration – response relations were obtained in the presence of amiloride to inhibit electrogenic sodium absorption and Ba2+ to prevent potassium secretion. 2. Single- or double-ring substitutions in 1,10 phenanthroline (EC50 = 612 muM) produced only modest increases in affinity of between 0.7- and 2.1-fold. 3. Naphthalenes with either one or two ring nitrogens showed some activity but had very low affinity, yet some (e.g. isoquinoline, EC50 = 700 muM) were able to produce maximal responses. 4. Removal of one nitrogen from 1,10-phenanthroline or from 4,7-phenanthroline gave, respectively, 7,8-benzoquinoline and 5,6-benzoquinoline. These two were the most active compounds found, the EC50 for 5,6-benzoquinoline being 29 muM. 5. Most concentration – response curves were steep with Hill slopes of approximately 3. At high concentration, some compounds inhibited the response, producing a characteristic bell shape. 6. 5,6- and 7,8-benzoquinoline may be useful starting points for the synthesis of more potent agents by the addition of ring substituents.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N117 – PubChem