Synthetic Route of 72702-95-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 72702-95-5, Name is 2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid, molecular formula is C17H12BrFN2O3. In a Article£¬once mentioned of 72702-95-5
Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis
The glyoxalase I inhibitor diester, S-p-bromobenzyl-glutathione cyclopentyl diester (BrBzGSHCp2), inhibited the growth of human leukaemia 60 (HL60) cells in vitro. The median growth inhibitory concentration GC50 value of BrBzGSHCp2 was 4.23 ¡À 0.01 muM (n = 21), and the median toxic concentration TC50 value was 8.86 ¡À 0.01 muM (n = 21). BrBzGSHCp2 inhibited DNA synthesis in the third of incubation: the median inhibitory concentration IC50 value was 6.11 ¡À 0.02 muM (n = 8). Incubation of HL60 cells with 10 muM BrBzGSHCp2 delivered the diester into cells: de-esterification of the diester therein lead to formation of the S-p-bromobenzylglutathione, inhibition of glyoxalase I activity in situ, increase in the methylglyoxal concentration after 1 hr, and induction of apoptosis after 6 hr. BrBzGSHCp2 (50-200 mg/kg) also inhibited the growth of murine adenocarcinoma 15A in vivo. Glyoxalase I inhibitor diesters may, therefore, inhibit tumour growth by inducing the accumulation of methylglyoxal in tumour cells, and induction of apoptosis.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 72702-95-5. In my other articles, you can also check out more blogs about 72702-95-5
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N921 – PubChem