Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C12H13FN2O. Introducing a new discovery about 1242156-59-7, Name is 6-(tert-Butyl)-8-fluorophthalazin-1(2H)-one
Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold
A rational fluorine scan based on co-crystal structures was explored to increase the potency of a series of selective BTK inhibitors. While fluorine substitution on a saturated bicyclic ring system yields no apparent benefit, the same operation on an unsaturated bicyclic ring can increase HWB activity by up to 40-fold. Comparison of co-crystal structures of parent molecules and fluorinated counterparts revealed the importance of placing fluorine at the optimal position to achieve favorable interactions with protein side chains.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C12H13FN2O, you can also check out more blogs about1242156-59-7
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N690 – PubChem