One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Phthalazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 253-52-1, Name is Phthalazine, molecular formula is C8H6N2
Uncommon solvent effect in oxidative addition of MeI to a new dinuclear platinum complex containing a platina(II)cyclopentane moiety
The reaction of the known complex cis,cis-[Me2Pt a(mu-dppm)-(mu-SMe2)Ptb-CH 2(CH2)2CcH2(Pt b-Cc)] [dppm = bis(diphenylphosphanyl) methane] with phthalazine (NN) proceeded by replacement of the labile bridging SMe2 ligand with the bidentate N-donor ligand NN to give cis,cis-[Me 2Pta(mu-dppm)-(mu-NN)Ptb-CH2(CH 2)2CcH2(Ptb-C c)] (1) as a pale red solid in good yield. The complex was fully characterized by multinuclear (1H, 31P, 195Pt) NMR spectroscopy. The subsequent reaction of complex 1 with excess MeI gave the colorless diplatinum( IV) complex [Me3Pta(mu-dppm)(mu- I)2Ptb{CH2(CH2)2C cH2-(Ptb-Cc)}Me], in which the bridging NN ligand is replaced by bridging iodido ligands. The reddish color of complex 1, which is due to a metal-to-ligand charge transfer (MLCT) band in the visible region, was used to monitor its reaction with MeI in the solvents acetone, CH22Cl2, and benzene. The kinetic data revealed that the reactions in nonpolar benzene or slightly polar CH2Cl 2 proceeded in two steps, each following a common SN2 mechanism. In the first step, MeI attacked the platina(II)cyclopentane center rather than the dimethylplatinum(II) center, because the first center is more electronrich than the second center. In the more polar acetone, the reaction proceeded similarly, with the exception that each step was accompanied by a solvolytic reaction, which was suggested to be responsible for the unusually slower reaction rate in acetone than in benzene or CH2Cl2. Consistently, the reaction rate in the highly polar solvent CH3CN was too slow for any meaningful measurement. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of Phthalazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N188 – PubChem