Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H6N2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 253-52-1
Fused azole-thiazolines: Via one-pot cyclization of functionalized N-heterocyclic carbene precursors
A one-pot two-step methodology was exploited to synthesize fused thiazoline-azolium salts via reactions of bromoalkyl-azolium salts with KSCN and NaOH. The synthetic feasibility and versatility was demonstrated by the high yield (>80%) preparation of 13 salts with different backbones, linkers and substituents. Using methylpropionato as an N-protecting group, the resulting salts could be further derivatized to their neutral azole-thiazolines. The reaction sequence proceeds via (i) Br ? SCN substitution, (ii) N-heterocyclic carbene formation, (iii) carbene attack of the S atom and CN- displacement in the alkyl-S-CN unit, and (iv) methyl acrylate elimination.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N439 – PubChem