253-52-1, Name is Phthalazine, belongs to phthalazine compound, is a common compound. COA of Formula: C8H6N2In an article, once mentioned the new application about 253-52-1.
Reactions of uracils. 21. Zwitterionic heteropolycyclic uracils by a novel three-component reaction: Iminophosphorane, isocyanate, heteroarene
The novel three-component reaction of (uracil-6-ylimino)phosphorane 1, isocyanate 2, and (substituted) pyridines gives, in a one-pot procedure, a variety of new pyrido[1′,2′:3,4]pyrimido[4,5-d]pyrimidines 3-11. The zwitterionic ground state of these new ring systems is i.a. established by means of solvatochromism, Hammett correlations, NMR, and X-ray analysis. Replacement of the pyridine by isoquinoline and phthalazine gives access to the novel ring systems pyrimido[4′,5′:4,5]pyrimido[6,1-a]isoquinoline and -phthalazine, which are formed as dihydro derivatives (14, 15) or as zwitterions (13, 17), depending on the reaction conditions. Oxidative cleavage of the phthalazine 15 in nitrobenzene affords the pyrimido[4,5-d]pyrimidines 16.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N466 – PubChem