3682-14-2, Name is 6-Amino-2,3-dihydrophthalazine-1,4-dione, belongs to phthalazine compound, is a common compound. Recommanded Product: 6-Amino-2,3-dihydrophthalazine-1,4-dioneIn an article, once mentioned the new application about 3682-14-2.
Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients
Vitamin K is a fat-soluble vitamin involved in blood coagulation and bone metabolism. The detection and monitoring of vitamin K homologues in rheumatoid arthritis (RA) patients is a challenging problem due to the smaller concentrations of vitamin K and the presence of several interfering medications. Therefore, this study aimed to develop a new highly sensitive and selective chemiluminescence (CL) method designated to quantify vitamin K homologues in plasma of RA patients including phylloquinone (PK, vitamin K1), menaquinone-4 (MK-4, vitamin K2) and menaquinone-7 (MK-7, vitamin K2). The method was based on the unique photochemical properties of vitamin K homologues that were exploited for selective luminol CL reaction. The correlation coefficients of 0.998 or more were obtained in the concentration ranges of 0.1-100 ng mL-1 vitamin K homologues. The detection limits were 0.03-0.1 ng mL-1 in human plasma for vitamin K homologues. The developed HPLC-CL system was successfully applied for selective determination of vitamin K homologues in plasma of RA patients. The developed method may provide a useful tool for monitoring vitamin K homologues in different clinical studies such as RA, osteoporosis and hepatocellular carcinoma in which vitamin K is intervented.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N522 – PubChem