Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 253-52-1. Introducing a new discovery about 253-52-1, Name is Phthalazine
[Bmim]OH mediated new synthesis 3-(1H-indol-3-yl)acrylonitrile derivatives
[Bmim]OH mediated new synthesis of 3-(1H-indol-3-yl)acrylonitrile derivatives 6 have been developed by the reaction of diethyl phthalate (1) with ethyl cyanoacetic acid hydrazide (2) to form 3-(1,4-dioxo-3,4-dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile (3). Then compound 3 reacted with indole-3-aldehyde (4) by Knoevenagel condensation to form compound 2-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2-carbonyl)-3-(1H-indol-3-yl)acrylonitriles (5). Compounds 5 undergo alkylation with alkylating agents to form 6 with good yields. Compounds 6 could also be synthesized by alkylation of 4 followed by condensation with 3.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 253-52-1, you can also check out more blogs about253-52-1
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N228 – PubChem