More research is needed about Phthalazine

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Vaporization, Sublimation Enthalpy, and Crystal Structures of Imidazo[1,2-a]pyrazine and Phthalazine

The vaporization enthalpy of imidazo[1,2-a]pyrazine is evaluated by correlation gas chromatography using two sets of standards and by transpiration. Vaporization enthalpies were evaluated using heterocyclic standards with dipole moments that vary from 0 to 3.0 D and using standards with dipole moments > 3.0 D. A value of (70.7 ¡À 1.0) kJ¡¤mol-1 measured by transpiration compares to (67.9 ¡À 1.4) kJ¡¤mol-1 measured by correlation gas chromatography using standards characterized by dipole moments > 3.0 D. The results suggest that imidazo[1,2-a]pyrazine is a member of this series of compounds whose vaporization enthalpies exceed those less polar heterocycles by a fairly constant amount, (6.9 ¡À 0.3) kJ¡¤mol-1, in this case by (5.9 ¡À 3.0) kJ¡¤mol-1 using the less polar heterocycles. The crystal structures of phthalazine, another member of the polar series, and of imidazo[1,2-a]pyrazine were determined to examine whether pi-pi stacking, present in the solid state of two other members of the polar series, was a characteristic of this series. If present in the liquid, pi-pi stacking could offer a possible explanation for the vaporization enthalpy differences observed. The sublimation enthalpy of imidazo[1,2-a]pyrazine was also evaluated.

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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N297 – PubChem