Reference of 3682-14-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 3682-14-2, 6-Amino-2,3-dihydrophthalazine-1,4-dione, introducing its new discovery.
The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils
Background Chronic Obstructive Pulmonary Disease (COPD) is characterised by increased neutrophilic inflammation. A potential novel anti-inflammatory target in COPD is phosphatidylinositol-3 kinase (PI3 kinase), which targets neutrophil function. This study evaluated the effects of selective PI3Kdelta inhibition on COPD blood and sputum neutrophils both in the stable state and during exacerbations. Methods Blood and sputum neutrophils from stable and exacerbating COPD patients were cultured with the corticosteroid dexamethasone, a pan PI3 kinase inhibitor (ZSTK474), a delta selective PI3 kinase inhibitor (GSK045) and a p38 mitogen activated protein (MAP) kinase inhibitor (BIRB 796); matrix metalloproteinase (MMP)-9 and reactive oxygen species (ROS) release were analysed. Results PI3Kdelta inhibition significantly reduced MMP-9, intracellular ROS and extracellular ROS release from blood neutrophils (45.6%, 30.1% and 47.4% respectively; p < 0.05) and intracellular ROS release from sputum neutrophils (16.6%; p < 0.05) in stable patients. PI3Kdelta selective inhibition significantly reduced stimulated MMP-9 (36.4%; p < 0.05) and unstimulated and stimulated ROS release (12.6 and 26.7%; p < 0.05) from blood neutrophils from exacerbating patients. The effects of the p38 MAP kinase inhibitor and dexamethasone in these experiments were generally lower than PI3Kdelta inhibition. Conclusion PI3Kdelta selective inhibition is a potential strategy for targeting glucocorticoid insensitive MMP-9 and ROS secretion from COPD neutrophils, both in the stable state and during exacerbations. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 3682-14-2. In my other articles, you can also check out more blogs about 3682-14-2
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Phthalazine – Wikipedia,
Phthalazine | C8H6N563 – PubChem