In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: phthalazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 3682-14-2, name is 6-Amino-2,3-dihydrophthalazine-1,4-dione. In an article£¬Which mentioned a new discovery about 3682-14-2
Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size
How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive oxygen species (ROS) as sensors of microbe size. By sensing the differential localization of ROS generated in response to microbes of different size, neutrophils tuned their interleukin (IL)-1beta expression via the selective oxidation of NF-kappaB, in order to implement distinct inflammatory programs. Small microbes triggered ROS intracellularly, suppressing IL-1beta expression to limit neutrophil recruitment as each phagocyte eliminated numerous pathogens. In contrast, large microbes triggered ROS extracellularly, amplifying IL-1beta expression to recruit numerous neutrophils forming cooperative clusters. Defects in ROS-mediated microbe size sensing resulted in large neutrophil infiltrates and clusters in response to small microbes that contribute to inflammatory disease. These findings highlight the impact of ROS localization on signal transduction.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N653 – PubChem