The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. 763111-47-3, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one, cas is 763111-47-3,the phthalazine compound. A new synthetic method of this compound is introduced below.
Orapanib intermediate (B) (0.77 kg, 2.10 mol) obtained in step (1) and triethylamine (0.88 kg, 6.32 mol) were added to methylene chloride (5.0 L) and stirred to control temperature 15 CAdd dropwise cyclopropyl carbonyl chloride (0.35L, 3.83mo 1), the dropwise addition, the reaction was stirred at 20-30 C 3h.Add appropriate amount of water, stirring 2h, suction filtration to obtain olaparib (0.79kg, a yield of 87%, a purity of 99.7%).
The chemical industry reduces the impact on the environment during synthesis,763111-47-3,4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; Shiyao Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Wang Liwei; Zhang Hongfen; Zheng Ligang; Ji Dehua; Sun Xiaowei; Yu Pu; Guo Xiaofeng; (8 pag.)CN106928149; (2017); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem