A new application about 1821-12-1

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In an article, author is Lashkari, Mojtaba, once mentioned the application of 1821-12-1, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00004403, category is phthalazines. Now introduce a scientific discovery about this category, Safety of 4-Phenylbutanoic acid.

A Facile Approach for One-Pot Synthesis of 1H-pyrazolo [1,2-b]phthalazine-5,10-dione Derivatives Catalyzed by ZrCl4 as an Efficient Catalyst Under Solvent-Free Conditions

A simple synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of zirconium tetrachloride (ZrCl4) as a mild and efficient Lewis acidic catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as high efficiency, inexpensive and non-toxic catalyst, environmentally benign nature, solvent-free conditions and simplicity of operation.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1821-12-1, Safety of 4-Phenylbutanoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem