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Synthesis and Antitumor Activity of Novel 1,3-Disubstituted Pyridazinone Derivatives
In order to find more efficient and low toxicity antitumor drugs, a series of novel 1,3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H)-yl)-N-(2-fluorophenyl)acetamide (5g) exhibited better antiproliferative activities with IC50 value of 6.01 mu mol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem