Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 789-25-3, Name is Triphenylsilane, molecular formula is C18H16Si, belongs to phthalazines compound, is a common compound. In a patnet, author is Amin, Kamilia M., once mentioned the new application about 789-25-3, Safety of Triphenylsilane.
Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity
Efforts to develop new antitumor agents are now directed towards multitarget therapies that are believed to have high potency and low tendency to resistance compared to conventional drugs. Herein, we highlighted the synthesis and antitumor activity of five series of phthalazine-based compounds featuring a variety of bioactive chemical fragments at position 1 of the phthalazine nucleus. The antitumor activity of the target compounds was performed against fourteen cancer cell lines where all compounds were active in the nanomolar level. In addition, the mechanism of action of the target compounds was investigated through an enzymatic inhibitory assay against VEGFR-2 and EGFR kinases, revealing potent and preferential activity toward VEGFR-2. Binding mode of the most active compounds was studied using docking experiment. (C) 2016 Elsevier Masson SAS. All rights reserved.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 789-25-3. The above is the message from the blog manager. Safety of Triphenylsilane.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem