Synthetic Route of 54381-16-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, belongs to phthalazines compound. In a article, author is Zaheer, Zahid, introduce new discover of the category.
Novel amalgamation of phthalazine-quinolines as biofilm inhibitors: One-pot synthesis, biological evaluation and in silico ADME prediction with favorable metabolic fate
A facile and highly efficient one-pot synthesis of phthalazine-quinoline derivatives is reported via four component reaction of phthalic anhydride, hydrazine hydrate, 5,5-dimethyl 1,3 cyclohexanedione and various quinoline aldehydes using PrxCoFe(2-x)O(4) (x = 0.1) nanoparticles as a catalyst. The synthesized compounds have been evaluated for anti-biofilm activity against Pseudomonas aeruginosa and Candida albicans. The compounds 12a (IC50 = 30.0 mu M) and 12f (IC50 = 34.5 mu M) had shown promising anti-biofilm activity against P. aeruginosa and C. albicans, respectively, when compared with standards without affecting the growth of cells (and thus behave as anti-quorum sensing agents). Compounds 12a (MIC = 45.0 mu g/mL) and 12f (MIC = 57.5 mu g/mL) showed significant potent antimicrobial activity against P. aeruginosa and C. albicans, respectively. Thus, the active derivatives were not only potent biofilm inhibitors but also efficient antimicrobial agents. In silico ADME and metabolic site prediction studies were also held out to set an effective lead candidate for the future antimicrobial drug discovery initiatives. (C) 2016 Elsevier Ltd. All rights reserved.
Synthetic Route of 54381-16-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 54381-16-7.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem