Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, SMILES is COC(OC)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1, in an article , author is Vinnakota, Chitra, once mentioned of 24650-42-8, Category: phthalazines.
An alpha 5 GABAA Receptor Inverse Agonist, alpha 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which no cognition-restoring therapies exist. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. Increasing evidence suggests a remodeling of the GABAergic system in AD, which might represent an important therapeutic target. An inverse agonist of alpha 5 subunit-containing GABAA receptors (alpha 5GABAARs), 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3-a]phthalazine (alpha 5IA) has cognition-enhancing properties. This study aimed to characterize the effects of alpha 5IA on amyloid beta (A beta(1-42))-induced molecular and cellular changes. Mouse primary hippocampal cultures were exposed to either A beta(1-42) alone, or alpha 5IA alone, alpha 5IA with A beta(1-42) or vehicle alone, and changes in cell viability and mRNA expression of several GABAergic signaling components were assessed. Treatment with 100 nM of alpha 5IA reduced A beta(1-42)-induced cell loss by 23.8% (p < 0.0001) after 6 h and by 17.3% after 5 days of treatment (p < 0.0001). Furthermore, we observed an A beta(1-42)-induced increase in ambient GABA levels, as well as upregulated mRNA expression of the GABAAR alpha 2,alpha 5,beta 2/3 subunits and the GABABR R1 and R2 subunits. Such changes in GABARs expression could potentially disrupt inhibitory neurotransmission and normal network activity. Treatment with alpha 5IA restored A beta(1-42)-induced changes in the expression of alpha 5GABAARs. In summary, this compound might hold neuroprotective potential and represent a new therapeutic avenue for AD. Interested yet? Read on for other articles about 24650-42-8, you can contact me at any time and look forward to more communication. Category: phthalazines.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem