618-88-2, Name is 5-Nitroisophthalic acid, molecular formula is C8H5NO6, belongs to phthalazines compound, is a common compound. In a patnet, author is Sen, Supriti, once mentioned the new application about 618-88-2, Recommanded Product: 5-Nitroisophthalic acid.
EFFICIENT AND CONVENIENT METHODS FOR SYNTHESIS OF SOME PHTHALAZINE DERIVATIVES AND THEIR EVALUATION OF CYTOTOXICITY
A systematic study of the reaction of 1,4-dihydrazinophthalazine (DHPH) with 1,3-dicarbonyls [viz., acetylacetone (acac), dibenzoylmethane (bzbz), and 1-benzoylacetone (bzac)] varying the reaction conditions was carried out to obtain the phthalazine derivatives (1-4). One-pot reaction of DHPH with acac led to the formation of two compounds 1 and 2, with various factors such as the presence of the acid or base, amount of the acac, time of reflux, and the temperature. The reaction conditions of DHPH with bzbz or bzac are sort of different to isolate the products 3 and 4, respectively. The derivatives (1-4) have been characterized by elemental analyses, H-1 NMR, and electrospray ionization-mass spectrometry (ESIMS) and the cytotoxic activity of the compounds 1-4 was evaluated on HeLa cell line. [Supplementary materials are available for this article. Go to the publisher’s online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 618-88-2. The above is the message from the blog manager. Recommanded Product: 5-Nitroisophthalic acid.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem