Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 623-25-6, Name is ¦Á,¦Á’-Dichloro-p-xylene, molecular formula is , belongs to phthalazines compound. In a document, author is Naeimi, Hossein, SDS of cas: 623-25-6.
Inorganic-organic hybrid chitosan-based Schiff base-Ni complex as a novel, highly efficient and recyclable heterogeneous catalyst for synthesis of pyrazolophthalazinediones
A Schiff base based on chitosan was synthesized through treatment of chitosan and p-dimethylaminobenzaldehyde in methanol solution. This biopolymeric Schiff base was used to prepare a new first row transition metal complex of Ni(II). The biopolymeric Schiff base and the synthesized tetra-coordinated complex were characterized using Fourier transform infrared, H-1 NMR and C-13 NMR techniques. Then, an efficient synthetic method for functionalized 1H-pyrazolo[1,2-b] phthalazine-5,10-diones was successfully developed using one-pot domino reaction of ninhydrin and malononitrile with 3-arylamino-5,5-dimethyl-2-cyclohexenones catalysed by the chitosan-based Schiff base complex of Ni(II) at room temperature. The advantages of this protocol are easy work-up, short reaction times and high yield of products and also the catalyst can be readily isolated from the reaction mixture and recycled without loss of catalytic activity.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem