A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C8H7BrO2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7507-86-0, Name is 2-Bromo-5-methoxybenzaldehyde, molecular formula is C8H7BrO2. In an article, author is Awadallah, Fadi M.,once mentioned of 7507-86-0.
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
New phthalazine-based vasodilators were synthesized through the chloroacylation of the starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7. These intermediates were used to alkylate various cyclic amines to furnish the final compounds 6a-h and 8a-h. Compounds were tested for their vasorelaxant activities against nor-adrenaline-induced spasm on thoracic rat aorta rings and compared to the reference drug, prazosin. Seven compounds showed higher activity than prazosin, especially compound 8d having an IC50 = 0.10 mM. Molecular modeling studies, including fitting of the synthesized compounds to a 3D-pharmacophore and their docking into optimized homology model as alpha(1)-AR antagonists showed high docking score and fit values. Most vasodilation activities of tested compounds are consistent with their molecular modeling results. (C) 2012 Elsevier Masson SAS. All rights reserved.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem