Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, molecular formula is C14H16BNO, belongs to phthalazines compound, is a common compound. In a patnet, author is Xin Jingchao, once mentioned the new application about 524-95-8, Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.
Synthesis and Antitumor Activity of 1-Phenyl-4-substituted Phthalazine Derivatives
In order to find more efficient and economical antitumor drugs, a series of 1-phenyl-4-substituted phthalazine derivatives were synthesized and evaluated for antiproliferative activity in vivo. The structures of the synthesized compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of the target compounds was performed against four cancer cell lines by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT). The results showed that some compounds had a good antitumor activity, especially, N-(4-methoxyphenyl)-2-((4-phenylphthalazin-1-yl)thio)acetamide (5f) and N-(3-chloro-4-fluorophenyl)-2-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)acetamide (8c), exhibited better antitumor activities with IC50 values of 8.13 and 9.31 mu mol.L-1 against the human esophageal cancer cells, which were superior to 5-fuorouracil.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 524-95-8. The above is the message from the blog manager. Recommanded Product: 2-((Diphenylboryl)oxy)ethanamine.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem