Synthetic Route of 524-95-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a article, author is Xue, Deng-Qi, introduce new discover of the category.
Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives
Trying to develop potent and selective anticancer agents, two series of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives were designed and synthesized. Their antitumor activities were evaluated by MU method against four selected human cancer cell lines (MGC-803, EC-9706, HeLa and MCF-7). Our results showed that compound 11h exhibited good anticancer activities compared to 5-fluorouracil against the four tested cell lines, with IC50 values ranging from 2.0 to 4.5 mu M. Flow cytometry analysis indicated that compound 11h induced the cellular early apoptosis and cell cycle arrest at G2/M phase in EC-9706. (C) 2014 Published by Elsevier Masson SAS.
Synthetic Route of 524-95-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 524-95-8.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem