Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ma, Long-Xu, once mentioned the application of 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00006953, category is phthalazine. Now introduce a scientific discovery about this category, Computed Properties of C10H12O.
Synthesis and positive inotropic evaluation of [1,2,4]triazolo [3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties
Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1,2,4]triazolo[3,4-a]phthalazin-6-yl) piperazin-1-yl)(p-tolyl) methanone (5g) being identified as the most potent with an increased stroke volume of 19.15 +/- 0.22% (milrinone: 2.46 +/- 0.07%) at a concentration of 3 x 10(-5) M. A preliminary study of mechanism of action revealed that 5g displayed its positive inotropic effect may be related to the PDE-cAMP-PKA signaling pathway. Compounds exhibiting inotropic effects were also evaluated in terms of the chronotropic effects. (c) 2014 Elsevier Ltd. All rights reserved.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem