In an article, author is El-Shamy, Ibrahim E., once mentioned the application of 767-00-0, Name: 4-Hydroxybenzonitrile, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, molecular weight is 119.12, MDL number is MFCD00002312, category is phthalazine. Now introduce a scientific discovery about this category.
Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxo-phthalazin-2yl] acetic acid hydrazide derivatives
The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16,19 in good yields. Furthermore, cc-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their corresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds. (C) 2014 Elsevier Ltd. All rights reserved.
If you are interested in 767-00-0, you can contact me at any time and look forward to more communication. Name: 4-Hydroxybenzonitrile.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem