Month: April 2021

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, in an article , author is Goli-Jolodar, Omid, once mentioned of 608141-42-0, Application In Synthesis of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Introduction of O-sulfonated poly(vinylpyrrolidonium) hydrogen sulfate as an efficient, and reusable solid acid catalyst for some solvent-free multicomponent reactions

In this work, O-sulfonated poly(vinylpyrrolidonium) hydrogen sulfate ([PVP-SO3H]HSO4) has been prepared as a powerful recyclable solid acid catalyst and characterized using a variety of techniques including elemental analysis, FT-IR, TGA, SEM, XRD, pH analysis and Hammett acidity function. After preparation and identification the mentioned solid acid with wide acidic functional group sites, is utilized as a highly efficient catalyst for the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones, 1-(benzothiazolylamino)phenylmethyl-2-naphthols and 2H-indazolo[2,1-b] phthalazine-1,6,11(13H)-triones in the absence of solvent. These eco-friendly protocols offer some advantages such as green and cost-effective procedures with excellent yields, shorter reaction times, simpler work-up, recovery, and reusability of a metal-free solid acid heterogeneous catalyst.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 608141-42-0, you can contact me at any time and look forward to more communication. Application In Synthesis of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O. In an article, author is El-Helby, Abdel-Ghany A.,once mentioned of 122-03-2, Safety of p-Isopropylbenzenecarboxaldehyde.

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking

In view of the anticonvulsant activity reported for phthalazine derivatives as non-competitive AMPA receptor antagonists, a new series of phthalazine-1,4-diones (2-12) were designed and synthesized. The neurotoxicity was assessed using rotarod test. The molecular docking was performed for the synthesized compounds to assess their binding affinities toward AMPA receptor as non-competitive antagonists. The molecular modeling data were strongly interrelated to biological screening data. Compounds 8, 7(b), 7(a), 10 and 3(a) exhibited the highest binding affinities as non-competitive AMPA receptor antagonists and also showed the highest relative potencies of 1.78, 1.66, 1.60, 1.59 and 1.29, respectively, as anticonvulsants in comparison with diazepam. The most active compounds 8, 7(b), 7(a), 10 and 3(a) were further tested against maximal electroshock seizure (MES). Compounds 8 and 7(b) and 3(a) showed 100% protection at a dose level of 125 mu gm/kg, while compounds 7(a) and 10 exhibited 83.33% protection at the same dose level. These agents exerted low neurotoxicity and high safety margin in comparison with valproate as a reference drug. Most of our designed compounds exhibited good ADMET profile.

Interested yet? Keep reading other articles of 122-03-2, you can contact me at any time and look forward to more communication. Safety of p-Isopropylbenzenecarboxaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2215-77-2, Name is 4-Phenoxybenzoic acid, molecular formula is C13H10O3, belongs to phthalazine compound. In a document, author is Szavuly, Miklos, introduce the new discover, SDS of cas: 2215-77-2.

Catalytic oxidation of alcohols and sulfides with hydrogen peroxide using isoindoline and phthalazine-based diiron complexes

A series of diiron(III) complexes of 1,3-bis(2′-arylimino)isoindoline, [(Fe(L)Cl)(2)O] and 1,4-di-(2′-aryl)aminophthalazine, [Fe-2(mu-OMe)(2)(H2L)Cl-4], including new structurally characterized ligands, 1,4-di-(4′-methyl-2′-thiazolyl)aminophthalazine and 1,4-di-(2′-benzthiazolyl)-aminophthalazine, have been characterized, and used as catalysts for the oxidation of para-substituted phenyl methyl sulfides and benzyl alcohols. Hammett correlations and kinetic isotope effect experiments support the involvement of electrophilic metal-based oxidants. In case of [(Fe(L-1,L-2)Cl)(2)O] catalysts, direct correlation has been found between the oxidative and catalase-like activity. (C) 2014 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2215-77-2. SDS of cas: 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5. In an article, author is Jahanshahi, Parivash,once mentioned of 4474-86-6, Recommanded Product: 4474-86-6.

Chemodivergent, multicomponent-tandem facile synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-dione using acetic acid functionalized imidazolium salt {[cmdmim]I} as a recyclable catalyst

A novel one-pot four-component, highly efficient and environmentally benign approach for the synthesis of a wide range of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in the presence of acetic acid functionalized imidazolium salt (1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I}) as a newly synthesized BrOnsted acid catalyst is described. The reaction occurs via tandem Knoevenagel-cyclocondensation of phthalic anhydride, hydrazine hydrate, aromatic aldehydes and 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile (or 3-(1H-indol-3-yl)-3-oxopropanenitrile) in the presence of acetic acid functionalized imidazolium salt {[cmdmim]I} in ethanol under reflux conditions. This adequate procedure possesses some advantages like atom economy, cost-effectiveness, operational simplicity, short reaction times, straightforward work-up procedure, high yields, and reusability of the catalyst in 5 consecutive runs without any appreciable decrease in activity.

Interested yet? Keep reading other articles of 4474-86-6, you can contact me at any time and look forward to more communication. Recommanded Product: 4474-86-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, in an article , author is Bai, Li-Gang, once mentioned of 117-34-0, Product Details of 117-34-0.

Base-promoted aerobic oxidation of N-alkyl iminium salts derived from isoquinolines and related heterocycles

Potassium tert-butoxide-promoted aerobic oxidation of N-alkyl iminium salts is reported. The reaction is atom-economical and environmentally friendly. Iminium salts derived from isoquinoline, quinoline, phenanthridine, phenanthroline, and phthalazine were successfully transformed into their corresponding unsaturated lactams with up to 95% yield under mild conditions in the absence of photocatalysts and metallic or organic catalysts. Owing to the general substrate scope, low cost, feasibility of scale up, wide availability of reagents, and green reaction conditions, this method shows great potential for preparing isoquinolones and related compounds. The method was applied for atom- and step-economical total synthesis of natural products such as norketoyobyrine.

Interested yet? Read on for other articles about 117-34-0, you can contact me at any time and look forward to more communication. Product Details of 117-34-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 4-Hydroxybenzonitrile, begins with the direct observation of nature— in this case, of matter.767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a document, author is Ghorbani-Vaghei, Ramin, introduce the new discover.

One-pot synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions

A series of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones were obtained from aldehydes, phthalhydrazide and malononitrile in good to excellent yields at 80-100 degrees C under solvent-free conditions by proceeding through a simple, mild and efficient procedure utilizing N, N, N’, N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] as catalysts.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 767-00-0. Recommanded Product: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 9,10-Dibromoanthracene, begins with the direct observation of nature— in this case, of matter.523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, belongs to phthalazine compound. In a document, author is Shirini, Farhad, introduce the new discover.

Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using 1,4-disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid catalyst

1,4-Disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid, is prepared and characterized by using different methods including FT-IR, NMR, Mass and SEM analysis as well as determination of the Hammett acidity function. This reagent can be used as an efficient catalyst for the promotion of the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives as important biologically active compounds with pharmaceutical properties. All reactions are performed in the absence of solvent using small amounts of the catalyst. Easy preparation of the catalyst, simple and easy work-up, mild reaction conditions, green process, excellent yields and short reaction times are the most important advantages this of method. (C) 2015 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 523-27-3. Recommanded Product: 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 620-14-4, Name is 3-Ethyltoluene, molecular formula is , belongs to phthalazine compound. In a document, author is Bashti, Aigin, Recommanded Product: 620-14-4.

Synthesis and characterization of dicationic 4,4 ‘-bipyridinium dichloride ordered mesoporous silica nanocomposite and its application in the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

The sol-gel method was used for the synthesis of a dicationic 4,4′-bipyridine silica hybrid nanocomposite. In order to introduce 4,4′-bipyridine into the skeleton framework of an ordered mesoporous silica (SBA-15), first, the N, N’-bis(triethoxysilylpropyl)-4,4′-bipyridinium dichloride precursor was synthesized by the reaction of 3-chloropropyltriethoxysilane with 4,4′-bipyridine to give (TEOS)(2)BiPy2+ 2Cl(-). The organic-inorganic hybrid nanocomposite, SBA@BiPy2+ 2Cl(-), was then synthesized by the hydrolysis and polycondensation of the precursor and tetraethyl orthosilicate under mild acidic conditions. The nanocomposite was characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET). The characteristic results of FT-IR, XRD and TGA confirmed the coexistence of silica and 4,4′-bipyridinium dichloride networks. The catalytic ability of SBA@BiPy2+ 2Cl(-) as a novel environmentally safe heterogeneous nanoreactor for the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via a one-pot multicomponent method under solvent-free conditions has been described. The catalyst can be reused without an obvious loss of catalytic activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 620-14-4, in my other articles. Recommanded Product: 620-14-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 35661-39-3, Name is Fmoc-Ala-OH, molecular formula is C18H17NO4, belongs to phthalazine compound, is a common compound. In a patnet, author is Shirini, Farhad, once mentioned the new application about 35661-39-3, Computed Properties of C18H17NO4.

Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using 1,4-disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid catalyst

1,4-Disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate {DABCO(HSO3)(2)(HSO4)(2)} as a new ionic liquid, is prepared and characterized by using different methods including FT-IR, NMR, Mass and SEM analysis as well as determination of the Hammett acidity function. This reagent can be used as an efficient catalyst for the promotion of the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives as important biologically active compounds with pharmaceutical properties. All reactions are performed in the absence of solvent using small amounts of the catalyst. Easy preparation of the catalyst, simple and easy work-up, mild reaction conditions, green process, excellent yields and short reaction times are the most important advantages this of method. (C) 2015 Elsevier Ltd. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 35661-39-3. The above is the message from the blog manager. Computed Properties of C18H17NO4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 103-36-6, Name is Ethyl cinnamate, molecular formula is , belongs to phthalazine compound. In a document, author is Makarem, S., Product Details of 103-36-6.

Electro-Organic Synthesis: An Efficient Method for the Preparation of Nanosized Particles of Phthalazine Derivatives via One-Pot Multicomponent Reactions

Aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. The method is based on the one-pot multicomponent reaction (MCRs) of phthalhydrazide, malononitrile and aldehydes in propanol employing undivided cell in the presence of NaBr as an electrolyte. The product was characterized, after purification, using IR, (HNMR)-H-1, C-13 NMR, MS and SEM. This procedure provides a method by which nanoparticles are synthesized directly from phthalhydrazide, malononitrile and aldehydes insides of a routine protocol for the synthesis of nano particles of organic compounds in which the synthesized organic compound is transformed into nanosized particles using modem high technology, for example ultrahighpressure rapid expansion of supercritical solution, and supercritical antisolvent with enhanced mass transfer. Size reduction is a fundamental unit operation having important applications in pharmacy. It helps to improve solubility and bioavailability, reduce toxicity, enhance release, and provide better formulation opportunities for drugs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 103-36-6, in my other articles. Product Details of 103-36-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem