Month: April 2021

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 104-53-0, Name is 3-Phenylpropanal, molecular formula is C9H10O, belongs to phthalazine compound. In a document, author is Kour, Manmeet, introduce the new discover, SDS of cas: 104-53-0.

Ionic liquid coated sulfonated carbon@titania composites for the one-pot synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media

A highly active and stable ionic liquid based novel solid Bronsted acid catalyst (C@TiO2-SO3H-ILs) was prepared by coating a long chain ionic liquid onto sulfonated carbon@titania composites. The ionic liquid coating resulted in efficient stability and activity of C@TiO2-SO3H-ILs under aqueous conditions by creating a hydrophobic environment on the catalyst surface. The catalytic activity of the newly designed catalyst was tested in the one-pot multicomponent synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media. The structure of the most active catalyst, C@TiO2-SO3H-IL1, before and after the coating with the ionic liquid was investigated by FTIR, TGA, XRD, CHNS, EDX, SEM and HRTEM. The catalyst allows easy recovery and excellent reusability for up to five catalytic runs without considerable loss of activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 104-53-0. SDS of cas: 104-53-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Safety of 4,4′-Methylenebis(2-methylaniline), begins with the direct observation of nature— in this case, of matter.838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), SMILES is NC1=CC=C(CC2=CC=C(C(C)=C2)N)C=C1C, belongs to phthalazine compound. In a document, author is Vafaee, Asieh, introduce the new discover.

An Efficient and High-yielding One-pot Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sodium Hydrogen Carbonate under Solvent-free Conditions

Sodium hydrogen carbonate, NaHCO3, efficiently catalyzes the one-pot, three-component reaction of phthalhydrazide, an aromatic aldehyde, and malononitrile or ethyl cyanoacetate under solvent-free conditions, to afford the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in high yields. Easy work up, inexpensive and readily available catalyst and avoiding the use of harmful organic solvents are other advantages of this simple procedure.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 838-88-0. Safety of 4,4′-Methylenebis(2-methylaniline).

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Name: 4-Hydroxybenzonitrile, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, belongs to phthalazine compound. In a document, author is Chalaki, Samaneh B..

Cu-II Anchored onto the Magnetic Talc: A New Magnetic Nanostructured Catalyst for the One-Pot Gram-Scale Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives

In the present study Cu(II)anchored onto the magnetic talc (gamma-Fe2O3/ talc /Cu(II)NPs) was successfully synthesized and characterized by FT-IR, XRD, TEM, FE-SEM, EDX, VSM, and ICP-OES techniques. Structural characterizations reveal that the gamma-Fe2O3/talc/Cu(II)NPs are superparamagnetic in nature, structured as a composite with average diameter of about 19-31 nm. The prepared nanostructured catalyst efficiently catalyzed the preparation of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones at the gram scale without the use of the toxic organic solvents. The magnetically separable and environmentally friendly nanostructured catalyst remains quite stable during reaction conditions and reused for at least five recycle runs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 767-00-0, in my other articles. Name: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ma, Long-Xu, once mentioned the application of 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00006953, category is phthalazine. Now introduce a scientific discovery about this category, Computed Properties of C10H12O.

Synthesis and positive inotropic evaluation of [1,2,4]triazolo [3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties

Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1,2,4]triazolo[3,4-a]phthalazin-6-yl) piperazin-1-yl)(p-tolyl) methanone (5g) being identified as the most potent with an increased stroke volume of 19.15 +/- 0.22% (milrinone: 2.46 +/- 0.07%) at a concentration of 3 x 10(-5) M. A preliminary study of mechanism of action revealed that 5g displayed its positive inotropic effect may be related to the PDE-cAMP-PKA signaling pathway. Compounds exhibiting inotropic effects were also evaluated in terms of the chronotropic effects. (c) 2014 Elsevier Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 122-03-2, Computed Properties of C10H12O.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 143-66-8, Name is Sodium tetraphenylborate, SMILES is C1([B-](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1.[Na+], belongs to phthalazine compound. In a document, author is Munin, Javier, introduce the new discover, Formula: C24H20BNa.

Synthesis and vasorelaxant and antiplatelet activities of a new series of (4-Benzylphthalazin-1-ylamino)alcohol derivatives

A new series of phthalazine derivatives was synthesized by reaction of phthalic anhydride and different substituted phenylacetic acids to yield the benzyliden-3H-isobenzofuran-1-one intermediates 2a-d. Treatment of them with hydrazine afforded 4-benzyl-2H-phthalazin-1-one derivatives 3a-d, which were substituted with the corresponding aminoalkylalcohol to obtain the (4-benzylphthalazin-1-ylamino)alcohol derivatives 4a-h. In general, these phthalazine derivatives relaxed the contractions produced by phenylephrine both in intact or endothelium-denuded aortic rings. In addition, platelet aggregation induced by thrombin was also inhibited by compounds 4c and 4g.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 143-66-8 is helpful to your research. Formula: C24H20BNa.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, in an article , author is Selvaraj, Keerthana, once mentioned of 1878-68-8, Product Details of 1878-68-8.

Tel-Cu-NPs Catalyst: Synthesis of Naphtho[2,3-g]phthalazine Derivatives as Potential Inhibiters of Tyrosinase Enzymes and Their Investigation in Kinetic, Molecular Docking, and Cytotoxicity Studies

Novel one-pot synthesis naphtho[2,3-g]phthalazine (1a-1k) of Mannich base derivatives can be achieved via grindstone chemistry using a Tel-Cu-NPs (telmisartan-copper nanoparticles) catalyst. This method offers efficient mild reaction conditions and high yields. Tyrosinase inhibitory activity was evaluated for all synthesized compounds, along with analysis of kinetic behavior and molecular docking studies. The synthesized compound, 1c was (IC50 = 11.5 mu M) more active than kojic acid (IC50 = 78.0 mu M). Lineweaver Burk plots were used to analyze the kinetic behavior of the most active compound 1c, it was reversible and competitive behavior. Compound 1c and kojic acid occurred in the presence of 2-hydroxyketone, which has the same inhibitory mechanism. The molecular docking of compound 1c and the control kojic acid were docked against 2Y9X protein via the Schrodinger Suite. The compound 1c showed a respectable dock score (-5.6 kcal/mol) compared to kojic acid with a dock score of (-5.2 kcal/mol) in the 2Y9X protein. Cytotoxicity activity was also evaluated by using HepG2 (liver), MCF-7 (breast), and HeLa (cervical) cancer cell lines, and high activity for 1c (GI(50) = 0.01, 0.03, and 0.04 mu M, respectively) against all cell lines was found compared to standard and other compounds. Therefore, this study succeeded in testing a few promising molecules as potential antityrosinase agents.

Interested yet? Read on for other articles about 1878-68-8, you can contact me at any time and look forward to more communication. Product Details of 1878-68-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 371-42-6, Name is 4-Fluorothiophenol, SMILES is SC1=CC=C(F)C=C1, belongs to phthalazine compound. In a document, author is Salehi, Peyman, introduce the new discover, Quality Control of 4-Fluorothiophenol.

Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 371-42-6 is helpful to your research. Quality Control of 4-Fluorothiophenol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 613-45-6, Name is 2,4-Dimethoxybenzaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Romero, Angel H., Recommanded Product: 2,4-Dimethoxybenzaldehyde.

Aryl- or heteroaryl-based hydrazinylphthalazine derivatives as new potential antitrypanosomal agents

A series of twenty phthalazinyl-hydrazones were synthesized and tested as potential anti-Trypanosoma cruzi agents. The phthalazines containing 5-nitroheteroaryl moiety 3l and 3m displayed an excellent in vitro antitrypanosomal profile, exhibiting low micromolar EC50 values against proliferative epimastigote of T. cruzi and minimal toxicity toward Vero cells. These derivatives were more potent than the reference drug benznidazole against the epimastigote stage of the parasite. Structure-property analysis indicates that the highly conjugated 5-nitroheteroaryl moiety connected to the phthalazin scaffold play an important role in the antichagasic activity of these phthalazines. The decrease on the mitochondrial dehydrogenase activity and significant ROS production found for the parasites treated with 3l and 3m suggest that both nitro-derivatives can act through an oxidative stress mechanism. (C) 2017 Elsevier Inc. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 613-45-6, in my other articles. Recommanded Product: 2,4-Dimethoxybenzaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 2935-35-5, 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Li Jiali, introduce the new discover.

Synthesis and Anticonvulsant Activity Evaluation of 6-Substituted-pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine Derivatives

In this paper, a series of 6-substituted-pyrido[3,2-e][1,2,4] triazolo[4,3-a] pyrazine derivatives have been synthesized. Their anticonvulsant activity and neurotoxicity in mice were evaluated by maximal electroshock (MES) and rotarod test, respectively. The structures were confirmed by H-1 NMR, C-13 NMR, MS and HRMS. The experimental results show that 6-phenoxypyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrazine (5g) was safer than the reference drug, carbamazepine, with ED50 value of 93.9 mg.kg(-1) and protective index (PI) value of 24.3, which was a potential anti-epilepsy candidate compound.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2935-35-5. Product Details of 2935-35-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a document, author is Reddy, Mudumala Veeranarayana, introduce the new discover, Recommanded Product: 2935-35-5.

Microwave-assisted, montmorillonite K-10 catalyzed three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An efficient, rapid, and green synthesis of 2H-indazolo[2,1-b]phthalazine-triones has been accomplished under solvent-free conditions by the reaction of phthalhydrazide, aldehydes and 5,5-dimethylcyclohexane-1,3-dione. This approach exploits the synthetic potential of microwave irradiation and Montmorillonite K-10 combination and offers many advantages, such as excellent product yields, shorter reaction time, reusable catalyst, easy isolation of products, and environmentally benign reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2935-35-5 is helpful to your research. Recommanded Product: 2935-35-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem