Month: April 2021

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 7524-50-7, Name is H-Phe-OMe.HCl, formurla is C10H14ClNO2. In a document, author is Deshpande, S. R., introducing its new discovery. Formula: C10H14ClNO2.

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

To understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 7524-50-7 help many people in the next few years. Formula: C10H14ClNO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 41263-74-5, Name is 4-(Methylamino)-3-nitrobenzoic acid, SMILES is O=C(O)C1=CC=C(NC)C([N+]([O-])=O)=C1, in an article , author is Uckun, Fatih M., once mentioned of 41263-74-5, Recommanded Product: 4-(Methylamino)-3-nitrobenzoic acid.

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)-dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceutical composition. This nanoscale liposomal formulation (NLF) contains the pentapeptide mimic 1,4-Bis (9-O dihydroquinidinyl) phthalazine/hydroquinidine 1,4-phathalazinediyl diether (C61) as the first and only selective inhibitor of the substrate binding P-site of SYK. The C61 NLF exhibited a very favorable pharmacokinetic and safety profile in mice, induced apoptosis in primary B-precursor ALL blast cells taken directly from patients as well as in vivo clonogenic ALL xenograft cells, destroyed the in vivo clonogenic fraction of ALL blast cells, and, at nontoxic dose levels, exhibited potent in vivo antileukemic activity against patient-derived ALL cells in xenograft models of aggressive B-precursor ALL. Our findings establish SYK as an attractive molecular target for therapy of B-precursor ALL. Further development of the C61 NLF may provide the foundation for therapeutic innovation against therapy-refractory B-precursor ALL.

Interested yet? Read on for other articles about 41263-74-5, you can contact me at any time and look forward to more communication. Recommanded Product: 4-(Methylamino)-3-nitrobenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 122-99-6, Name is 2-Phenoxyethanol, molecular formula is C8H10O2. In an article, author is Abouzid, Khaled A. M.,once mentioned of 122-99-6, Quality Control of 2-Phenoxyethanol.

Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, molecular formula is , belongs to phthalazine compound. In a document, author is Im, Jeong Kyun, Product Details of 54381-16-7.

N-Chlorination-induced, oxidative ring contraction of 1,4-dimethoxyphthalazines

A rarely explored oxidative ring contraction of electron-rich 1,2-diazine is described. Upon treatment with an electrophilic chlorinating reagent (TCICA), 1,4-dimethoxyphthalazines undergo an N-chlorination-induced ring contraction that is accompanied by the loss of one nitrogen atom. The scope of this unusual reactivity was examined with a range of 1,4-dimethoxyphthalazine derivatives. In addition, a mechanism proceeding via a bicyclic species was proposed on the basis of an isolated reaction intermediate and DFT calculations. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 54381-16-7, Product Details of 54381-16-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: phthalazines23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=C2C=C(OC)C=CC2=C1, belongs to phthalazine compound. In a article, author is Shahsavani, Mohammad Bagher, introduce new discover of the category.

Anticancer activity assessment of two novel binuclear platinum (II) complexes

In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis,cis-[Me2Pt(mu-NN)(mu dppm,) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells. Using different biophysical techniques and docking simulation analysis, we indicated that these complexes were also capable to interact efficiently with DNA via a non-intercalative mechanism. According to our results, substitution of cyclopentane (in complex 2) with two methyl groups (in complex 1) results in significant improvement of the complex ability to interact with DNA and subsequently to induce the anticancer activity. Overall, these binuclear Pt (II) complexes are promising group of the non-classical potential anticancer agents which can be considered as molecular templates in designing of highly efficient platinum anticancer drugs. (C) 2016 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 23981-47-7. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5267-64-1, Name is D-Penylalaninol, molecular formula is C9H13NO. In an article, author is Tayebee, Reza,once mentioned of 5267-64-1, Name: D-Penylalaninol.

Heteropolyacid-based ionic liquid [Simp](3)PW12O40 nanoparticle as a productive catalyst for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

A novel Keggin-type heteropolyacid-based ionic liquid [Simp](3)PW12O40 was developed via the reaction of the as synthesized ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 with an aqueous solution of H3PW12O40. Then, the formulated [Simp](3)PW12O40 was changed to the nano-form via solvothermal processing in tetralin at 220 degrees C. After that, the provided powdered solid nanomaterial was characterized by FTIR, H-1 NMR, XRD, SEM, EDX and TGA analyses. Then, the focused nanomaterial was handled as a productive and encouraging nanocatalyst for the establishment of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione attendants through one-pot, multi-component contraction of aldehydes, phthalhydrazide, and dimedone under solventless status and the generality and practical tolerance of this useful and environmentally benign method are illustrated. The simple work-up, smooth reaction conditions, good to excellent yields, and reasonably short reaction times are the particular benefits of this protocol. Besides, the new nano-powdered ionic liquid was a successful and modest catalyst that could definitely be recycled and reused several times without apparent decrease in its catalytic activity. (C) 2017 Elsevier B.V. All rights reserved.

If you’re interested in learning more about 5267-64-1. The above is the message from the blog manager. Name: D-Penylalaninol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H10O4, Safety of [1,1′-Biphenyl]-2,2′-dicarboxylic acid, belongs to phthalazine compound, is a common compound. In a patnet, author is Eldehna, Wagdy M., once mentioned the new application about 482-05-3.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl) phthalazine derivatives

A series of anilinophthalazine derivatives 4a-j was initially synthesized and tested for its VEGFR-2 inhibitory activity where it showed promising activity (IC50 = 0.636-5.76 mu M). Molecular docking studies guidance was used to improve the binding affinity for series 4a-j towards VEGFR-2 active site. This improvement was achieved by increasing the hydrophobic interaction with the hydrophobic back pocket of the VEGFR-2 active site lined with the hydrophobic side chains of Ile888, Leu889, Ile892, Val898, Val899, Leu1019 and Ile1044. Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into the hydrophobic back pocket. As planned, the designed uriedo-anilinophthalazines 7a-i showed superior binding affinity than their anilinophthalazine parents (IC50 = 0.083-0.473 mu M). In particular, compounds 7g-i showed IC50 of 0.086, 0.083 and 0.086 mu M, respectively, which are better than that of the reference drug sorafenib (IC50 = 0.09 mu M). (C) 2016 Elsevier Masson SAS. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 482-05-3 help many people in the next few years. Safety of [1,1′-Biphenyl]-2,2′-dicarboxylic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 2,2-Diphenylacetic acid, 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, in an article , author is Wang, Haitao, once mentioned of 117-34-0.

Enantioselective Fluorocyclizations Mediated by Amino-Acid-Derived Phthalazine

Novel amino-acid-derived phthalazine reagents have been designed and synthesized for the enantioselective fluorocyclizations of prochiral indoles. The scope of reaction is evidenced by 28 examples of fluorinated furoindole and pyrroloindole heterocycles bearing various functionalities with up to 99% ee. The resulting enantioenriched fluorinated products are found to be potent AChE inhibitors. Advantages of the current new chiral reagents include ease in the synthesis of analogues and readily tunable steric/electronic demands.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 117-34-0, you can contact me at any time and look forward to more communication. Recommanded Product: 2,2-Diphenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mohamadpour, Farzaneh, once mentioned the application of 14348-75-5, Name is 2,7-Dibromo-9H-fluoren-9-one, molecular formula is C13H6Br2O, molecular weight is 337.99, MDL number is MFCD00010790, category is phthalazine. Now introduce a scientific discovery about this category, Computed Properties of C13H6Br2O.

Carboxymethyl Cellulose (CMC) as a Recyclable Green Catalyst Promoted Eco-Friendly Protocol for the Solvent-Free Synthesis of 1H-Pyrazolo[1,2-b]Phthalazine-5,10-Dione Derivatives

An eco-safe synthetic route for convenient one-pot synthesizing 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives through Knoevenagel-Michael cyclocondensation is reported in carboxymethyl cellulose (CMC) based on green chemistry principles. The prominent benefits include use of recyclable green catalyst, commercially accessible inexpensive starting materials, operational simplicity, non-hazardous reaction circumstances, high atom-economy, solvent-free, short reaction times and high yields.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14348-75-5, Computed Properties of C13H6Br2O.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 402-50-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, SMILES is FC(F)(F)C1=CC=C(C=C)C=C1, belongs to phthalazine compound. In a article, author is Gol’dberg, A. E., introduce new discover of the category.

Crystal structure of a trinuclear complex of zinc(II) with 2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone

2,6-Di-tert-butyl-p-quinone 1′-phthalazynylhydrazone (HL) is synthesized; the total energies and geometry of the possible hydrazone tautomeric forms are calculated by quantum chemical methods. The hydrazone phthalazone tautomer is shown to be the most stable, which is well consistent with the H-1 NMR spectroscopic data for hydrazone. An X-ray crystallographic analysis is performed of the hydrazone-based Zn(II) trinuclear complex, in which zinc atoms are linked by the diazine bridge of the phthalazine cycle and two pivalate bridges. The geometric properties of the monodeprotonated hydrazone residue in the complex are similar to the calculated data for the phthalazone hydrazone tautomeric form.

Application of 402-50-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 402-50-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem