Month: April 2021

In an article, author is Hiremath, Prashant B., once mentioned the application of 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, molecular formula is C14H16BNO, molecular weight is 225.09, MDL number is MFCD00014823, category is phthalazines. Now introduce a scientific discovery about this category, Recommanded Product: 524-95-8.

Microwave-Accelerated Facile Synthesis of 1H-Pyrazolo[1,2-b]Phthalazine-5,10-Dione Derivatives Catalyzed by WEMPA

An efficient and rapid one-pot multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones through condensation of aldehyde, malononitrile and phthalhydrazide catalyzed by agro-waste solvent catalyst-derived water extract of mango peel ash (WEMPA) under microwave irradiation is described. Further, the catalyst is prepared from agricultural waste and characterized for elemental composition by different techniques such as SEM-EDX, XRD and flame photometry. This green synthetic approach offers various advantages such as inexpensive, abundantly available source, shorter reaction time (6-8 min), good-to-excellent yield (83%-89%), simple workup and a sustainable alternative method to the existing protocols. All the synthesized compounds (4a-l) was confirmed by FT-IR,H-1-NMR,C-13-NMR and LC-MS.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 17852-52-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, SMILES is O=S(C1=CC=C(NN)C=C1)(N)=O.[H]Cl, belongs to phthalazines compound. In a article, author is Sadimenko, Alexander P., introduce new discover of the category.

Organometallic Complexes of Azines

Organometallic complexes of practically unsubstituted (non-chelating) azines and their benzannulated derivatives, possible N-heterocyclic carbenes containing at least one double bond, and boron-, boronenitrogen, silicon-, tri- and hexaphosphorus analogs of azines are considered in the view of their synthetic availability, coordination modes, and possible application in catalysis and materials chemistry.

Synthetic Route of 17852-52-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 17852-52-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 2215-77-2, Name is 4-Phenoxybenzoic acid, SMILES is OC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1, belongs to phthalazines compound. In a document, author is Tang, Ruizhi, introduce the new discover, COA of Formula: C13H10O3.

Aromatic azaheterocycle-cored luminogens with tunable physical properties via nitrogen atoms for sensing strong acids

A series of luminogens comprising one pyridine, 1,3-diazine, 1,4-diazine, 1,2-diazine and phthalazine moiety as the central core and two AIE-active tetraphenylethene units in lateral positions have been readily synthesized by Suzuki cross-coupling. They exhibited remarkably different photophysical and electrochemical properties, as well as solid packing and fine controllability via the number and position of the nitrogen atoms in the aromatic azaheterocycle core. Among them, the pyridine, 1,3-diazine and 1,4-diazine-cored luminogens displayed strong AIE activities, whereas the 1,2-diazine and phthalazine-cored luminogens exhibited almost no AIE effect. The intrinsic Lewis basicity of the as-prepared luminogens endowed them with the ability to fluorometrically detect acids with different pK(a) values. When protonated by a strong acid such as trifluoroacetic acid, the pyridine, 1,3-diazine and 1,4-diazine-cored luminogens displayed relatively weak AIE effects. In contrast, the 1,2-diazine and phthalazine-cored luminogens exhibited highly sensitive responses to strong acids within a precise pKa range by displaying turn-on fluorescence emissions in the low-energy region, which was probably owing to the synergetic effect of AIE and the constraint of the intersystem crossing effect upon protonation of the 1,2-diazine segment. They displayed reversible acidochromism in response to protonation and deprotonation in the solid state. Such unique properties of the as-prepared luminogens could be used for the selective discrimination of some organic acids, which is highly valuable in the study of biological metabolism.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2215-77-2 is helpful to your research. COA of Formula: C13H10O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 3648-20-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 3648-20-2, Name is Diundecyl phthalate, SMILES is O=C(OCCCCCCCCCCC)C1=CC=CC=C1C(OCCCCCCCCCCC)=O, belongs to phthalazines compound. In a article, author is Boraei, Ahmed T. A., introduce new discover of the category.

Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma

Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a privilege moiety that is incorporated in a big number of anticancer drugs in clinical use or that are still under clinical or preclinical studies. We utilized the drug extension strategy to tailor the designed compounds to fit the EGFR hydrophobic sub pocket and cleft region. The designed phthalazine derivatives was synthesized by linking phthalazine moiety with 1,3,4-oxadiazole-thione and 1,2,4-triazole-thione. Alkylation and glycosylation of the new heterocyclic systems were successfully performed to be used in the drug extension. Coupling of some phthalazine derivatives with different amino acids was also performed to improve the drug selectivity. The synthesized compounds were tested for their antiproliferative activity against cancer cells both in vivo and in vitro. The in vitro activity against hepatocellular carcinoma (HepG2 cell line) ranged from 5.7 mu g/mL to 43.4 mu g/mL. Compounds 31a and 16 were the most active with an IC(50)5.7 mu g/mL and 7.09 mu g/mL, respectively compared to the standard compound doxorubicin (4.0 mu g/mL). In vivo, compounds 10 and 16 showed IC50 values 7.25 mu g/mL and 7.5 mu g/mL, respectively compared to the standard compound cisplatin (IC50, 9.0 mu g/mL). In silico, testing of the phthalazine derivatives showed that they are good inhibitors for EGFR. The docking studies substantiated compounds 4, 10, 16 and 31a as new lead compounds and identified Arg841 as a key residue in the cleft region for binding stronger inhibitors.

Electric Literature of 3648-20-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 3648-20-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Fandzloch, Marzena, once mentioned the application of 608141-42-0, Safety of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, molecular weight is 273.3486, MDL number is MFCD22677268, category is phthalazines. Now introduce a scientific discovery about this category.

Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi

Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cisfactRuCl(2)(clinso)(3)(tmtP)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]center dot 2H(2)O (2) and fac,cis-[RuCl3(H2O)(tmtp)(2)] (3). Their structures were characterized using X-ray and spectroscopic methods (IR, NMR or EPR). The stability of the synthesized complexes 1-3 in various buffered solutions (pH = 3-7.4) was monitored using conventional and stopped-flow techniques. The in vitro antiproliferative activity of all ruthenium complexes against promastigote forms of Leishmania spp. (L. infarztum, L. braziliensis, and L. donovani) and epimastigote forms of Trypanosoma cruzi was investigated. Notably, the results showed that the activity of 1 against L. brasiliensis was more than three-fold higher than that of glucantime, and 1 showed no appreciable toxicity towards J774.2 macrophages. Additionally, 2 displayed even 141-fold lower toxicity against host cells than glucantime, demonstrating significantly higher selectivity than the reference drug. Therefore, 1 and 2 appear to be excellent candidates for further development as potential drugs for the effective treatment of leishmaniasis and Chagas disease. All novel complexes were also shown to be potent inhibitors of Fe-SOD in the studied species, while their effects on human CuZn-SOD were very low.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 523-27-3, Name is 9,10-Dibromoanthracene, formurla is C14H8Br2. In a document, author is Xin, Lijun, introducing its new discovery. Application In Synthesis of 9,10-Dibromoanthracene.

Efficient near-infrared-emitting cationic iridium complexes based on highly conjugated cyclometalated benzo[g]phthalazine derivatives

Two near-infrared-(NIR-) emitting cationic iridium(III) complexes, [Ir(dpbpa)(2)(Bphen)]+PF6- (1) and [Ir(dtbpa)(2)(Bphen)]+PF6- (2), were rationally designed and synthesized, where dpbpa, dtbpa, and Bphen represent 1,4-diphenylbenzo[g]-phthalazine, 1,4-di(thiophen-2-yl)benzo[g]phthalazine and 4,7-dipheny1,10-phenanthroline, respectively. By using highly conjugated cyclometalated benzo[g]phthalazine ligands, these two complexes exhibited a significantly large red shift in wavelength to the truly NIR region with maximum peaks at 715 nm for 1 and 775 nm for 2. Complex 1 exhibited unexpectedly improved quantum efficiency up to 6.1% in the solid films. Based on these solution-processable phosphors, NIR organic-light-emitting devices (OLEDs) have been fabricated and demonstrated negligible efficiency roll-off with nearly constant external quantum efficiency around 0.5% over a wide range of current density of 1-100 mA cm(-2). Density functional theory calculations were performed to discover that the newly cyclometalated benzo[g]phthalazine ligands have several areas of superiority over the previous benzo[g]quinoline ligands in views of stronger Ir-N bonds, smaller chelate congestion, higher electron-accepting ability, thus improving the overall phosphorescence of the corresponding iridium complexes in the NIR region.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is C14H8Br2, belongs to phthalazines compound, is a common compound. In a patnet, author is Wang, Shi-Ben, once mentioned the new application about 523-27-3, Application In Synthesis of 9,10-Dibromoanthracene.

Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines

A series of 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazine derivatives were synthesized using 2,3-dihydrophthalazine-1,4-dione as starting material. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and MS data. Anticonvulsant activities of these compounds were evaluated by maximal electroshock (MES) test following intraperitoneal injection in mice. Among the synthesized compounds 3a-3t, compound 3e was the most active compound with an ED50 of 28.9 mg/kg, TD50 of 173.6 mg/kg and protective index (PI) of 6.0.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

103-45-7, Name is Phenethyl acetate, molecular formula is C10H12O2, belongs to phthalazines compound, is a common compound. In a patnet, author is Yan, Xiaohui, once mentioned the new application about 103-45-7, Name: Phenethyl acetate.

Inhibition of water adsorption into polar solid-phase microextraction materials with ultrathin polydimethylsiloxane coating for thermal desorption-gas chromatography analysis

Solid-phase microextraction (SPME) coupled with thermal desorption-gas chromatography (TD-GC) has become a powerful analysis tool for volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) in water samples. However, water adsorption into polar microextraction phase is usually unavoidable during the extraction process, and the burst of large amounts of water vapour during thermal desorption will cause serious problems to GC separation and detectors. Pawliszyn’s group had demonstrated that the tens of micron-thick, defect-free polydimethylsiloxane (PDMS) coating could act as a perfect barrier for water adsorption and offer much better compatibility in complex matrices. However, the PDMS overcoat largely decreased the uptake rate of polar analytes into the inner sorbent. In order to quantify the effect of PDMS coating thickness on water adsorption amount and the extraction kinetics, ultrathin PDMS layer was used to coat the polar extraction phase with polyimide (PI) as a model in this work. It was surprising to find that the PDMS coating with the thickness less than one micron can decrease the water adsorption by 96%, while the extraction efficiency for polar analytes (phenolic compounds and nitroaromatic explosives) was decreased by less than 20% at the extraction time of 30 min. Moreover, the kinetic data showed that the thinner the PDMS coating was, the less the uptake rate of polar analytes into PI extraction phase decreased. Finally, polar poly (phthalazine ether sulfone ketone) (PPESK) extraction phase was also coated with ultrathin PDMS coating to verify the universality of the strategy. Generally, the water adsorption problem in polar SPME was overcome to a great extent, and the extraction efficiency of polar analytes was mainly preserved with this ultrathin PDMS coating, which could broaden the application of SPME in the environmental field. (C) 2018 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 13001-40-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 13001-40-6, Name is 4,4′-(1,4-Phenylenebis(ethene-2,1-diyl))dibenzonitrile, SMILES is N#CC1=CC=C(/C=C/C2=CC=C(/C=C/C3=CC=C(C=C3)C#N)C=C2)C=C1, belongs to phthalazines compound. In a article, author is Franich, Andjela A., introduce new discover of the category.

New dinuclear palladium(II) complexes with benzodiazines as bridging ligands: interactions with CT-DNA and BSA, and cytotoxic activity

Three new dinuclear Pd(II) complexes with general formula [{Pd(en)Cl}(2)(mu-L)](NO3)(2) [L is bridging ligand quinoxaline (Pd1), quinazoline (Pd2) and phthalazine (Pd3)] were synthesized and characterized by elemental microanalyses, UV-Vis, IR and NMR (H-1 and C-13) spectroscopy. The interaction of dinuclear Pd1-Pd3 complexes with calf thymus DNA (CT-DNA) has been monitored by viscosity measurements, UV-Vis and fluorescence emission spectroscopy in aqueous phosphate buffer solution (PBS) at pH 7.40 and 37 degrees C. In addition, these experimental conditions have been applied to investigate the binding affinities of Pd1-Pd3 complexes to the bovine serum albumin (BSA) by fluorescence emission spectroscopy. In vitro antiproliferative and apoptotic activities of the dinuclear Pd(II) complexes have been tested on colorectal and lung cancer cell lines. All tested Pd(II) complexes had lower cytotoxic effect than cisplatin against colorectal cancer cells, but also had similar or even higher cytotoxicity than cisplatin against lung cancer cells. All complexes induced apoptosis of colorectal and lung cancer cells, while the highest antiproliferative effect exerted Pd2 complex. [GRAPHICS]

Electric Literature of 13001-40-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 13001-40-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 402-49-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazines compound. In a article, author is Kidwai, Mazaahir, introduce new discover of the category.

A Rapid and an Efficient Route to the One-pot, Multicomponent Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Ring Systems

CAN is found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via one-pot coupling reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in PEG as solvent. The major attributes of this synthetic protocol are the use of nontoxic, inexpensive, and readily available catalyst, mild conditions, easy work up, improved yields, and the PEG 400 as solvent that is environmentally benign as well as recyclable.

Reference of 402-49-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 402-49-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem