Month: April 2021

In an article, author is Reddy, Mudumala Veeranarayana, once mentioned the application of 623-25-6, Formula: C8H8Cl2, Name is ¦Á,¦Á’-Dichloro-p-xylene, molecular formula is C8H8Cl2, molecular weight is 175.06, MDL number is MFCD00000920, category is phthalazines. Now introduce a scientific discovery about this category.

InCl3-catalyzed green synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones under solvent-free conditions

A simple, efficient, and green practical approach to 1H-pyrazolo[1,2-b]phthalazine-5,10-diones from phthalhydrazide, aldehydes, and malononitrile/ethyl cyanoacetate has been developed that uses inexpensive and readily available InCl3 as a catalyst in solvent-free one-pot three-component cyclo condensation reaction. This method should provide high yields, shorter reaction time, easy work-up, purification of products by nonchromatographic method, and cleaner reaction. It is a new strategy for N-fused heterocycles synthesis, which haswider application in organic and medicinal chemistry. (c) 2013 Elsevier Ltd. All rights reserved.

If you are interested in 623-25-6, you can contact me at any time and look forward to more communication. Formula: C8H8Cl2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 117-34-0, Name is 2,2-Diphenylacetic acid. In a document, author is Schweighauser, Luca, introducing its new discovery. Formula: C14H12O2.

Bidentate Lewis Acid Catalyzed Domino Diels-Alder Reaction of Phthalazine for the Synthesis of Bridged Oligocyclic Tetrahydronaphthalenes

A domino process consisting of an inverse and a normal electron-demand Diels-Alder reaction is presented for the formation of bridged tri- and tetracyclic 1,2,3,4-tetrahydronaphthalenes catalyzed by a bidentate Lewis acid. The products were synthesized in a one-pot reaction from commercially available starting materials and contain up to six stereogenic centers. The tetrahydronaphthalenes were isolated as single diastereomers and are derivatives of phenylethylamine, which is well-known as a scaffold of amphetamine or dopamine.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 117-34-0 help many people in the next few years. Formula: C14H12O2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 1078-61-1, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1078-61-1, Name is 3-(3,4-Dihydroxyphenyl)propionic acid, molecular formula is C9H10O4. In an article, author is Varaksin, Mikhail V.,once mentioned of 1078-61-1.

Direct C-C coupling of phthalazine-N-oxide with the carboranyl anion – An original approach to C-modification of carboranes

An original transition metal-free approach based on the direct C-C coupling of phtalazine-N-oxide with the carboranyl anion has been developed. A series of the novel C-modified closo-carboranes such as 1-(2-oxido-3-acy1-3,4-dihydrophtalazinyl-4-yl)-1,2-dicarba-closo-dodecaboranes and 1-(2-formylbenzyl)-1,2-dicarba-closo-dodecaborane have been obtained. The synthesized boron clusters could be of interest as promising building blocks in design of BNCT delivery agents. (C) 2016 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 1439-36-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazines compound. In a article, author is Simijonovic, Dusica, introduce new discover of the category.

Synthesis, structural characterization, and molecular docking study of new phthalhydrazide-coumarin hybrids

A series of new phthalhydrazide-coumarin hybrids was obtained in the reaction of phthalhydrazide with corresponding bromopropoxycoumarin derivatives. These reactions were performed in the presence of Cs2CO3, in acetonitrile as solvent, and under reflux for 5 h. Obtained hybrids contain one or two coumarin scaffolds bonded to phthalhydrazide nitrogen via propoxy linker. Ten new phthalhydrazide-coumarin hybrids were obtained in moderate to good yields, and characterized with melting point, elemental analysis, IR and NMR spectroscopy, and LC-MS spectrometry. Additionally, the structures of these compounds were elucidated based on experimental and theoretical data (IR, H-1 NMR, and C-13 NMR). Excellent agreement between experimental and simulated spectra was achieved. The prediction of the potential biological activity of synthesized compounds was done using the online program PASS (Prediction of Activity Spectra for Substances). Based on the obtained results, the serotonin 2A receptor (5-HT2AR) was selected for molecular docking study. Molecular docking was also performed with commercially available drug Risperidone, and obtained results were compared with potential bioactive conformations of obtained phthalhydrazide-coumarin hybrids. (C) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 1439-36-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1439-36-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 7524-50-7, Name is H-Phe-OMe.HCl, SMILES is N[C@@H](CC1=CC=CC=C1)C(OC)=O.[H]Cl, in an article , author is Aliveisi, Rahman, once mentioned of 7524-50-7, Safety of H-Phe-OMe.HCl.

A DFT Study of Electronic Structures and Relative Stabilities of Isomeric n,m-Diazaphenanthrenes

In this study, the structural properties, energetic data, and classification of the chemical properties of n,m-diazaphenanthrine derivatives were studied by a density functional theory (DFT) method. The important and proper indices were applied in this investigation. The structures, electronic properties, and chemical reactivities of 25 isomeric n,m-diazaphenanthrenes were studied by a B3LYP/6?31+G(d) method/basis set. All the optimized geometries of these isomers kept good planarity. The structural properties such as bond lengths and dipole moments of these isomers were calculated. The energies of frontier orbitals (HOMO and LUMO) are used to determine several chemical reactivity parameters as a measure of their relative stabilities. These include total energy (E), ionization potential (I), electron affinity (A), chemical hardness (?), chemical softness (S), electronic chemical potentials (?), and electrophilicity (?). Based on these calculations, the heats of formation (?H?(f)) for all the n,m-diazaphenanthrine derivatives are predicted. Benzo[h]quinazoline (P-13) and benzo[f]cinnoline (P-34) are calculated to be the most stable and the least stable isomers, respectively. 1,10-Phenanthroline (P-110) possesses the minimum electrophilicity, while benzo[c]cinnoline (P-56) is calculated to have the highest electrophilicity among the isomeric structures. The largest and smallest dipole moments are calculated for benzo[f]phthalazine (P-23) and 3,8-phenanthroline (P-38), respectively. Linear relationships between the calculated E-LUMO (in eV) values and electrophilicity (?) of the isomeric n,m-diazaphenanthrenes were observed.

Interested yet? Read on for other articles about 7524-50-7, you can contact me at any time and look forward to more communication. Safety of H-Phe-OMe.HCl.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3. In an article, author is Zhang Luye,once mentioned of 81-48-1, SDS of cas: 81-48-1.

Synthesis and Antitumor Activity of Novel 1,3-Disubstituted Pyridazinone Derivatives

In order to find more efficient and low toxicity antitumor drugs, a series of novel 1,3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H)-yl)-N-(2-fluorophenyl)acetamide (5g) exhibited better antiproliferative activities with IC50 value of 6.01 mu mol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.

Interested yet? Keep reading other articles of 81-48-1, you can contact me at any time and look forward to more communication. SDS of cas: 81-48-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 623-25-6, Name is ¦Á,¦Á’-Dichloro-p-xylene, molecular formula is C8H8Cl2. In an article, author is Mohammad, Faruq,once mentioned of 623-25-6, Safety of ¦Á,¦Á’-Dichloro-p-xylene.

ONE-POT FOUR COMPONENT REACTION FOR THE SYNTHESIS OF 1-(1H-INDOL-2-YL)-1H-PYRAZOLO [1,2-b]PHTHALAZINE-5,10-DIONE DERIVATIVES BY SELF-CATALYSIS

In this, we performed a four component domino reaction of phthaloyl dichloride, hydrazine hydrate, indole-3-carboxaldehydes and malononitrile/ethyl cyanoacetate to form 1-(1H-indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by in situ generation of HCl as catalyst in refluxing ethanol for 1 h in good yields. This four component domino reaction transformation presumably proceeds via addition/dehydrohalogenation/condensation/cyclization of reactions. The material was thoroughly characterized at various stages of its formation by means of FTIR, NMR spectroscopic and Mass spectrometric analysis and is confirmed to be the derivative of 1-(1H-indo1-2-yl)-1H-pyrazolo [1,2-b]phthalazine-5,10-dione.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2935-35-5, Name is H-Phg-OH, SMILES is O=C(O)[C@@H](N)C1=CC=CC=C1, belongs to phthalazines compound. In a document, author is Atar, Amol B., introduce the new discover, Computed Properties of C8H9NO2.

beta-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst for the first time. [GRAPHICS] .

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2935-35-5 is helpful to your research. Computed Properties of C8H9NO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 139-66-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 139-66-2, Name is Diphenylsulfane, SMILES is C1(SC2=CC=CC=C2)=CC=CC=C1, belongs to phthalazines compound. In a article, author is Shekouhy, Mohsen, introduce new discover of the category.

Ultrasound-promoted catalyst-free one-pot four component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in neutral ionic liquid 1-butyl-3-methylimidazolium bromide

A catalyst-free one-pot four component methodology for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction medium is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and/or electron releasing groups as well as heteroaromatic aldehydes) were applied successfully, and corresponding products were obtained in good to excellent yields without any byproduct. (C) 2011 Elsevier B.V. All rights reserved.

Reference of 139-66-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 139-66-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, formurla is C14H10O4. In a document, author is Zhu, Guanxing, introducing its new discovery. COA of Formula: C14H10O4.

Access to a Phthalazine Derivative Through an Angular cis-Quinacridone

Intramolecular electrophilic cyclization of a bisanthranilate afforded an angular cis-quinacridone compound, which condensed with hydrazine to give a phthalazine derivative. A [2+2+2] cyclization reaction occurred at the C-N double bond position of phthalazine when reacted with dimethyl acetylenedicarboxylate. The structures of these novel compounds were confirmed by crystallographic analysis. The phthalazine derivative decomposes back to quinacridone at ambient condition in the dark and as a solid with a half lifetime of about 22 months.

If you are hungry for even more, make sure to check my other article about 482-05-3, COA of Formula: C14H10O4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem